Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 1016926..1017545 Replicon chromosome
Accession NZ_CP041866
Organism Mycobacterium tuberculosis strain 1-0036P6C4

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag FPJ40_RS04780 Protein ID WP_003404726.1
Coordinates 1017111..1017545 (+) Length 145 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ06
Locus tag FPJ40_RS04775 Protein ID WP_003898641.1
Coordinates 1016926..1017105 (+) Length 60 a.a.

Genomic Context

FPJ40_RS04760FPJ40_RS04765FPJ40_RS04770FPJ40_RS04775FPJ40_RS04780FPJ40_RS04785FPJ40_RS04790FPJ40_RS04795FPJ40_RS04800FPJ40_RS04805
Location: 1012399..1013979 (1581 bp)
Type: Others
Protein ID: WP_003909313.1
Location: 1013976..1016369 (2394 bp)
Type: Others
Protein ID: WP_003898639.1
Location: 1016642..1016800 (159 bp)
Type: Others
Protein ID: WP_003404720.1
Location: 1016926..1017105 (180 bp)
Type: Antitoxin
Protein ID: WP_003898641.1
Location: 1017111..1017545 (435 bp)
Type: Toxin
Protein ID: WP_003404726.1
Location: 1017643..1018416 (774 bp)
Type: Others
Protein ID: WP_003404735.1
Location: 1018481..1018930 (450 bp)
Type: Others
Protein ID: WP_003404738.1
Location: 1019065..1019295 (231 bp)
Type: Others
Protein ID: WP_003898642.1
Location: 1019462..1020970 (1509 bp)
Type: Others
Protein ID: WP_003404742.1
Location: 1020972..1022210 (1239 bp)
Type: Others
Protein ID: WP_003404744.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FPJ40_RS047601012399..1013979+1581WP_003909313.1serine hydrolase-
FPJ40_RS047651013976..1016369+2394WP_003898639.1cation-translocating P-type ATPase-
FPJ40_RS047701016642..1016800+159WP_003404720.1hypothetical protein-
FPJ40_RS047751016926..1017105+180WP_003898641.1antitoxinAntitoxin
FPJ40_RS047801017111..1017545+435WP_003404726.1SRPBCC family proteinToxin
FPJ40_RS047851017643..1018416+774WP_003404735.1VOC family protein-
FPJ40_RS047901018481..1018930+450WP_003404738.1hypothetical protein-
FPJ40_RS047951019065..1019295-231WP_003898642.1hypothetical protein-
FPJ40_RS048001019462..1020970-1509WP_003404742.1carotenoid oxygenase family protein-
FPJ40_RS048051020972..1022210-1239WP_003404744.1acetyl-CoA acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideProphage--1012291..107202259731


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-50)


Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15754.47 Da        Isoelectric Point: 9.7977

>T133972 WP_003404726.1 NZ_CP041866:1017111-1017545 [Mycobacterium tuberculosis]
MAKLSGSIDVPLPPEEAWMHASDLTRYREWLTIHKVWRSKLPEVLEKGTVVESYVEVKGMPNRIKWTIVRYKPPEGMTLN
GDGVGGVKVKLIAKVAPKEHGSVVSFDVHLGGPALLGPIGMIVAAALRADIRESLQNFVTVFAG

Download         Length: 435 bp

>T133972 NZ_CP041866:1017111-1017545 [Mycobacterium tuberculosis]
ATGGCGAAACTGTCCGGATCCATCGACGTACCGCTGCCACCGGAGGAAGCCTGGATGCACGCCTCCGATCTGACTCGTTA
CCGAGAGTGGCTGACCATCCACAAGGTATGGCGCAGCAAGTTGCCCGAAGTGCTCGAGAAGGGCACGGTCGTCGAGTCGT
ATGTCGAGGTCAAGGGCATGCCCAACCGGATCAAGTGGACGATCGTGCGGTACAAACCCCCGGAGGGCATGACGCTCAAC
GGCGACGGTGTGGGTGGTGTCAAAGTCAAGCTGATCGCTAAGGTAGCGCCGAAAGAGCACGGCTCCGTCGTCAGCTTCGA
TGTGCACCTCGGCGGCCCGGCCCTGCTCGGGCCGATCGGCATGATCGTCGCCGCTGCATTGCGAGCCGACATCCGCGAAT
CGCTGCAGAACTTCGTCACGGTGTTTGCCGGCTGA

Antitoxin


Download         Length: 60 a.a.        Molecular weight: 6403.07 Da        Isoelectric Point: 4.5393

>AT133972 WP_003898641.1 NZ_CP041866:1016926-1017105 [Mycobacterium tuberculosis]
MGILDKVKNLLSQNADKVETVINKAGEFVDEQTQGNYSDAIHKLHDAASNVVGMSDQQS

Download         Length: 180 bp

>AT133972 NZ_CP041866:1016926-1017105 [Mycobacterium tuberculosis]
ATGGGAATCCTGGACAAGGTAAAGAACCTGCTGTCGCAGAACGCCGACAAGGTCGAGACGGTGATCAACAAAGCGGGCGA
ATTCGTCGACGAGCAGACGCAAGGCAATTATTCTGACGCCATCCACAAGCTGCATGACGCGGCCAGCAACGTCGTCGGCA
TGAGCGACCAGCAGAGCTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A045KDK5

References