Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/RHH-GNAT |
| Location | 3837736..3838496 | Replicon | chromosome |
| Accession | NC_003197 | ||
| Organism | Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 | ||
Toxin (Protein)
| Gene name | tacT | Uniprot ID | - |
| Locus tag | STM3651 | Protein ID | NP_462552.1 |
| Coordinates | 3837748..3838233 (-) | Length | 162 a.a. |
Antitoxin (Protein)
| Gene name | tacA | Uniprot ID | - |
| Locus tag | STM3652 | Protein ID | NP_462553.1 |
| Coordinates | 3838221..3838508 (-) | Length | 96 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| STM3645 | 3832818..3833480 | + | 663 | NP_462546.1 | putative outer membrane lipoprotein | - |
| STM3646 | 3833699..3834673 | + | 975 | NP_462547.1 | 2-keto-D-gluconate reductase | - |
| STM3647 | 3834723..3835433 | - | 711 | NP_462548.1 | putative outer membrane lipoprotein | - |
| STM3648 | 3835872..3836162 | + | 291 | NP_462549.1 | putative transcriptional regulator | - |
| STM3649 | 3836451..3836663 | + | 213 | NP_462550.1 | major cold shock protein 7.4 | - |
| STM3650 | 3836837..3837376 | + | 540 | NP_462551.1 | putative periplasmic or exported protein | - |
| STM3651 | 3837748..3838233 | - | 486 | NP_462552.1 | putative acetyltransferase | Toxin |
| STM3652 | 3838221..3838508 | - | 288 | NP_462553.1 | putative cytoplasmic protein | Antitoxin |
| STM3653 | 3838686..3839153 | - | 468 | NP_462554.1 | putative acetyltransferase | - |
| STM3655 | 3839782..3841851 | - | 2070 | NP_462555.1 | glycine tRNA synthetase, beta subunit | - |
| STM3656 | 3841861..3842772 | - | 912 | NP_462556.1 | glycine tRNA synthetase, alpha subunit | - |
| STM3657 | 3842911..3843213 | - | 303 | NP_462557.1 | putative outer membrane lipoprotein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 162 a.a. Molecular weight: 17703.41 Da Isoelectric Point: 9.8719
>T443 NP_462552.1 NC_003197:c3838233-3837748 [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q
Download Length: 486 bp
>T443 NC_003197:c3838233-3837748 [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG
Antitoxin
Download Length: 96 a.a. Molecular weight: 10950.60 Da Isoelectric Point: 4.6811
>AT443 NP_462553.1 NC_003197:c3838508-3838221 [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV
Download Length: 288 bp
>AT443 NC_003197:c3838508-3838221 [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCTGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCTGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| T10041 | Mycobacterium tuberculosis H37Rv |
50.327 |
95.031 |
0.478 |
| T10051 | Salmonella enterica subsp. enterica serovar Typhimurium strain NCTC12023 |
47.436 |
96.894 |
0.46 |
| T199 | Escherichia coli O157:H7 str. EDL933 |
45.098 |
95.031 |
0.429 |
Multiple sequence alignment
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| AT199 | Escherichia coli O157:H7 str. EDL933 |
48.193 |
88.298 |
0.426 |
| AT10051 | Salmonella enterica subsp. enterica serovar Typhimurium strain NCTC12023 |
38.272 |
85.263 |
0.326 |
| AT10041 | Mycobacterium tuberculosis H37Rv |
37.349 |
87.368 |
0.326 |
Multiple sequence alignment
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|
References
(1) Angela M Cheverton et al. (2016) A Salmonella Toxin Promotes Persister Formation through Acetylation of tRNA. Molecular Cell 63(1):86-96. [PubMed:27264868]
(2) Chelsey M VanDrisse et al. (2017) A Toxin Involved in Salmonella Persistence Regulates Its Activity by Acetylating Its Cognate Antitoxin, a Modification Reversed by CobB Sirtuin Deacetylase. MBio 8(3):e00708-17. [PubMed:28559487]