Detailed information of TA system    

experimentalExperimentally validated    

Overview

TA module


Type II Classification (family/domain) tacAT/-
Location 3092210..3092991 Replicon chromosome
Accession UFRD01000002
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain NCTC12023

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag NCTC12023_03333 Protein ID SUH98649.1
Coordinates 3092210..3092701 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID -
Locus tag NCTC12023_03334 Protein ID SUH98650.1
Coordinates 3092698..3092991 (-) Length 98 a.a.

Genomic Context

NCTC12023_03328NCTC12023_03331NCTC12023_03332NCTC12023_03335NCTC12023_03336NCTC12023_03337NCTC12023_03330NCTC12023_03333NCTC12023_03334NCTC12023_03339
Location: 3088205..3088780 (576 bp)
Type: Others
Protein ID: SUH98645.1
Location: 3089623..3090000 (378 bp)
Type: Others
Protein ID: SUH98647.1
Location: 3091210..3091962 (753 bp)
Type: Others
Protein ID: SUH98648.1
Location: 3093793..3094668 (876 bp)
Type: Others
Protein ID: SUH98651.1
Location: 3094680..3094904 (225 bp)
Type: Others
Protein ID: SUH98652.1
Location: 3095104..3095466 (363 bp)
Type: Others
Protein ID: SUH98653.1
Location: 3089219..3089551 (333 bp)
Type: Others
Protein ID: SUH98646.1
Location: 3092210..3092701 (492 bp)
Type: Toxin
Protein ID: SUH98649.1
Location: 3092698..3092991 (294 bp)
Type: Antitoxin
Protein ID: SUH98650.1
Location: 3095760..3096620 (861 bp)
Type: Others
Protein ID: SUH98654.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
NCTC12023_033283088205..3088780+576SUH98645.1transcriptional regulator-
NCTC12023_033303089219..3089551-333SUH98646.1MerR family transcriptional regulator-
NCTC12023_033313089623..3090000+378SUH98647.1ethyl tert-butyl ether degradation EthD-
NCTC12023_033323091210..3091962+753SUH98648.1acid phosphatase-
NCTC12023_033333092210..3092701-492SUH98649.1N-acetyltransferase GCN5Toxin
NCTC12023_033343092698..3092991-294SUH98650.1Uncharacterized protein conserved in bacteriaAntitoxin
NCTC12023_033353093793..3094668+876SUH98651.1AraC family transcriptional regulator-
NCTC12023_033363094680..3094904+225SUH98652.1GerE family regulatory protein-
NCTC12023_033373095104..3095466+363SUH98653.1putative phage protein-
NCTC12023_033393095760..3096620-861SUH98654.1membrane protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T10051 SUH98649.1 UFRD01000002:c3092701-3092210 [Salmonella enterica subsp. enterica serovar Typhimurium]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T10051 UFRD01000002:c3092701-3092210 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGATCTCCACCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATAGATAACTG
GCTGGAACAGCGGGCGATGAAAAATCAGACCACTGGCGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCTCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGGTTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTCGCTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGTGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTATCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT10051 SUH98650.1 UFRD01000002:c3092991-3092698 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT10051 UFRD01000002:c3092991-3092698 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATCGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAAGCTGCCCGCGCTGCCGCAGAGGAAGCGCTTA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGAGTTTCTCGTTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
T443Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

47.436

96.894

0.46

T10041Mycobacterium tuberculosis H37Rv

46.795

95.706

0.448

T199Escherichia coli O157:H7 str. EDL933

41.83

95.031

0.398
Showing 1 to 3 of 3 rows

Multiple sequence alignment    


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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
AT199Escherichia coli O157:H7 str. EDL933

41.489

100

0.415

AT443Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

38.272

85.263

0.326
Showing 1 to 2 of 2 rows

Multiple sequence alignment    




Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References

(1) Julian A Rycroft et al. (2018) Activity of acetyltransferase toxins involved in Salmonella persister formation during macrophage infection. Nature Communications 9(1):1993. [PubMed:29777131] experimental

(2) Grzegorz J Grabe et al. (2021) Auxiliary interfaces support the evolution of specific toxin-antitoxin pairing. Nature Chemical Biology 17(12):1296-1304. [PubMed:34556858] 3D_structure


experimental experimental literature
3D_structure protein structure literature