Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 1034290..1035104 | Replicon | chromosome |
| Accession | NZ_CP075138 | ||
| Organism | Salmonella enterica strain CFSAN044875 | ||
Toxin (Protein)
| Gene name | TacT3 | Uniprot ID | A0A8E6Q2X6 |
| Locus tag | A7R97_RS05025 | Protein ID | WP_023228035.1 |
| Coordinates | 1034290..1034817 (-) | Length | 176 a.a. |
Antitoxin (Protein)
| Gene name | TacA3 | Uniprot ID | M7S6I2 |
| Locus tag | A7R97_RS05030 | Protein ID | WP_000855694.1 |
| Coordinates | 1034814..1035104 (-) | Length | 97 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| A7R97_RS04995 (1030501) | 1030501..1030899 | + | 399 | Protein_982 | cytoplasmic protein | - |
| A7R97_RS05000 (1031090) | 1031090..1031329 | + | 240 | Protein_983 | hypothetical protein | - |
| A7R97_RS05005 (1031486) | 1031486..1032154 | + | 669 | WP_000445915.1 | hypothetical protein | - |
| A7R97_RS05010 (1032181) | 1032181..1032675 | + | 495 | WP_000424947.1 | hypothetical protein | - |
| A7R97_RS05015 (1032919) | 1032919..1033575 | - | 657 | WP_000420452.1 | protein-serine/threonine phosphatase | - |
| A7R97_RS05020 (1033808) | 1033808..1034217 | + | 410 | Protein_987 | IS5/IS1182 family transposase | - |
| A7R97_RS05025 (1034290) | 1034290..1034817 | - | 528 | WP_023228035.1 | GNAT family N-acetyltransferase | Toxin |
| A7R97_RS05030 (1034814) | 1034814..1035104 | - | 291 | WP_000855694.1 | DUF1778 domain-containing protein | Antitoxin |
| A7R97_RS05035 (1035374) | 1035374..1035574 | - | 201 | Protein_990 | transposase | - |
| A7R97_RS05040 (1035815) | 1035815..1036141 | + | 327 | WP_000393302.1 | hypothetical protein | - |
| A7R97_RS05045 (1036414) | 1036414..1036761 | - | 348 | WP_077957157.1 | DUF1493 family protein | - |
| A7R97_RS05050 (1036746) | 1036746..1037195 | - | 450 | WP_000381612.1 | membrane protein | - |
| A7R97_RS05055 (1037626) | 1037626..1038069 | - | 444 | WP_000715096.1 | SPI-1 type III secretion system invasion lipoprotein InvH | - |
| A7R97_RS05060 (1038526) | 1038526..1039176 | + | 651 | WP_001674874.1 | type III secretion system transcriptional activator InvF | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| inside | Genomic island | - | invH / invF / invG / invE / invA / invB | 1034077..1044489 | 10412 | ||
| - | flank | IS/Tn | - | - | 1034077..1034217 | 140 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 176 a.a. Molecular weight: 19038.89 Da Isoelectric Point: 9.6420
>T203238 WP_023228035.1 NZ_CP075138:c1034817-1034290 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDPPLSLLL
SFKTLYAALSASGRL
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDPPLSLLL
SFKTLYAALSASGRL
Download Length: 528 bp
>T203238 NZ_CP099898:2362942-2363328 [Escherichia albertii]
ATGATTTGGGTCAGTGCACAGGAGGTCATTGCCTTCCACGATCGAATTTTGCAACGTTTTCCCGGTGTGGCGGGCCTGAC
TGACCCCGGCAGAGCACAGGCGTTGATTTATCGCGTGCAGAATCGTGTTCACTACGAGGGCGTTACTGACCTGTTTGAAC
TGGCAGCAACCTACTGGGTTGCCATCGCTCGCGGTCACATCTTTCATGATGGTAATAAACGTACCGCATTTTTCGTTACT
ATGACCTTTCTTTGGCGCAATGGCATCCGTATCCGTGACGTTGATAACTCGCTGGAGAACCTGACTGTCGAAGCGGCTAC
CGGAGAAAAAACGGTCGGTCAATTAGCGCGATGTTTACGTGAACGAGTGGATAGTTCCGGGAATTAA
ATGATTTGGGTCAGTGCACAGGAGGTCATTGCCTTCCACGATCGAATTTTGCAACGTTTTCCCGGTGTGGCGGGCCTGAC
TGACCCCGGCAGAGCACAGGCGTTGATTTATCGCGTGCAGAATCGTGTTCACTACGAGGGCGTTACTGACCTGTTTGAAC
TGGCAGCAACCTACTGGGTTGCCATCGCTCGCGGTCACATCTTTCATGATGGTAATAAACGTACCGCATTTTTCGTTACT
ATGACCTTTCTTTGGCGCAATGGCATCCGTATCCGTGACGTTGATAACTCGCTGGAGAACCTGACTGTCGAAGCGGCTAC
CGGAGAAAAAACGGTCGGTCAATTAGCGCGATGTTTACGTGAACGAGTGGATAGTTCCGGGAATTAA
Antitoxin
Download Length: 97 a.a. Molecular weight: 10664.50 Da Isoelectric Point: 6.3133
>AT203238 WP_000855694.1 NZ_CP075138:c1035104-1034814 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK
Download Length: 291 bp
>AT203238 NZ_CP099898:2362724-2362945 [Escherichia albertii]
ATGCAAACTTACACTTCCACACAAGCCAGAGCCAATATTGCCACTGTACTGGATACCGCGTTGAATGGTGAGCCAGTTGA
AATCACCCGTCGCGACGGCAGCTCTGCCGTGCTCATTAGTAAAGCCGCATTCGAGGCGTATCAAAATGCGAAACTGGACG
CGGAATTTGATGCCATCATGCAACGTCATGAACACACAATTGAAGCGTTGACTGATCGATGA
ATGCAAACTTACACTTCCACACAAGCCAGAGCCAATATTGCCACTGTACTGGATACCGCGTTGAATGGTGAGCCAGTTGA
AATCACCCGTCGCGACGGCAGCTCTGCCGTGCTCATTAGTAAAGCCGCATTCGAGGCGTATCAAAATGCGAAACTGGACG
CGGAATTTGATGCCATCATGCAACGTCATGAACACACAATTGAAGCGTTGACTGATCGATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|