284495

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1003862..1004676 Replicon chromosome
Accession NZ_CP128261
Organism Salmonella enterica subsp. enterica serovar Heidelberg isolate FT3-7B

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A633KU44
Locus tag QR684_RS04815 Protein ID WP_000971648.1
Coordinates 1003862..1004389 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag QR684_RS04820 Protein ID WP_000855694.1
Coordinates 1004386..1004676 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QR684_RS04795 (999072) 999072..1001639 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
QR684_RS04800 (1001798) 1001798..1002319 + 522 WP_000858988.1 hypothetical protein -
QR684_RS04805 (1002491) 1002491..1003147 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
QR684_RS04810 (1003380) 1003380..1003789 + 410 Protein_943 IS5/IS1182 family transposase -
QR684_RS04815 (1003862) 1003862..1004389 - 528 WP_000971648.1 GNAT family N-acetyltransferase Toxin
QR684_RS04820 (1004386) 1004386..1004676 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
QR684_RS04825 (1004946) 1004946..1005124 - 179 Protein_946 IS3 family transposase -
QR684_RS04830 (1005365) 1005365..1005691 + 327 WP_000393301.1 hypothetical protein -
QR684_RS04835 (1005964) 1005964..1006311 - 348 WP_001669174.1 DUF1493 family protein -
QR684_RS04840 (1006296) 1006296..1006745 - 450 WP_000381611.1 hypothetical protein -
QR684_RS04845 (1007177) 1007177..1007620 - 444 WP_000715096.1 SPI-1 type III secretion system invasion lipoprotein InvH -
QR684_RS04850 (1008077) 1008077..1008727 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 1003649..1014040 10391
- flank IS/Tn - - 1003649..1003789 140


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19040.90 Da        Isoelectric Point: 9.3905

>T284495 WP_000971648.1 NZ_CP128261:c1004389-1003862 [Salmonella enterica subsp. enterica serovar Heidelberg]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHALQNHEKGTTKTYVALDNSDITRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT284495 WP_000855694.1 NZ_CP128261:c1004676-1004386 [Salmonella enterica subsp. enterica serovar Heidelberg]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A633KU44

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References