Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 990743..991557 Replicon chromosome
Accession NZ_CP117388
Organism Salmonella enterica subsp. enterica serovar Uganda strain RM010

Toxin (Protein)


Gene name TacT3 Uniprot ID -
Locus tag PQQ04_RS04810 Protein ID WP_000971658.1
Coordinates 990743..991270 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag PQQ04_RS04815 Protein ID WP_000855694.1
Coordinates 991267..991557 (-) Length 97 a.a.

Genomic Context

PQQ04_RS04780PQQ04_RS04785PQQ04_RS04790PQQ04_RS04795PQQ04_RS04805PQQ04_RS04825PQQ04_RS04845PQQ04_RS04800PQQ04_RS04810PQQ04_RS04815PQQ04_RS04820PQQ04_RS04830PQQ04_RS04835PQQ04_RS04840
Location: 986954..987351 (398 bp)
Type: Others
Protein ID: Protein_935
Location: 987542..987730 (189 bp)
Type: Others
Protein ID: Protein_936
Location: 987938..988606 (669 bp)
Type: Others
Protein ID: WP_000445914.1
Location: 988633..989127 (495 bp)
Type: Others
Protein ID: WP_000424948.1
Location: 990261..990670 (410 bp)
Type: Others
Protein ID: Protein_940
Location: 992268..992594 (327 bp)
Type: Others
Protein ID: WP_000393305.1
Location: 994979..995629 (651 bp)
Type: Others
Protein ID: WP_001674874.1
Location: 989372..990028 (657 bp)
Type: Others
Protein ID: WP_000420452.1
Location: 990743..991270 (528 bp)
Type: Toxin
Protein ID: WP_000971658.1
Location: 991267..991557 (291 bp)
Type: Antitoxin
Protein ID: WP_000855694.1
Location: 991827..992027 (201 bp)
Type: Others
Protein ID: Protein_943
Location: 992867..993214 (348 bp)
Type: Others
Protein ID: WP_001669174.1
Location: 993199..993648 (450 bp)
Type: Others
Protein ID: WP_000381612.1
Location: 994080..994523 (444 bp)
Type: Others
Protein ID: WP_079798511.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
PQQ04_RS04780 (986954)986954..987351+398Protein_935cytoplasmic protein-
PQQ04_RS04785 (987542)987542..987730+189Protein_936hypothetical protein-
PQQ04_RS04790 (987938)987938..988606+669WP_000445914.1hypothetical protein-
PQQ04_RS04795 (988633)988633..989127+495WP_000424948.1hypothetical protein-
PQQ04_RS04800 (989372)989372..990028-657WP_000420452.1protein-serine/threonine phosphatase-
PQQ04_RS04805 (990261)990261..990670+410Protein_940IS5/IS1182 family transposase-
PQQ04_RS04810 (990743)990743..991270-528WP_000971658.1GNAT family N-acetyltransferaseToxin
PQQ04_RS04815 (991267)991267..991557-291WP_000855694.1DUF1778 domain-containing proteinAntitoxin
PQQ04_RS04820 (991827)991827..992027-201Protein_943IS3 family transposase-
PQQ04_RS04825 (992268)992268..992594+327WP_000393305.1hypothetical protein-
PQQ04_RS04830 (992867)992867..993214-348WP_001669174.1DUF1493 family protein-
PQQ04_RS04835 (993199)993199..993648-450WP_000381612.1membrane protein-
PQQ04_RS04840 (994080)994080..994523-444WP_079798511.1SPI-1 type III secretion system invasion lipoprotein InvH-
PQQ04_RS04845 (994979)994979..995629+651WP_001674874.1type III secretion system transcriptional activator InvF-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideGenomic island-invH / invF / invG / invE / invA / invB990530..100094210412
-flankIS/Tn--990530..990670140


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19051.87 Da        Isoelectric Point: 9.6420

>T271039 WP_000971658.1 NZ_CP117388:c991270-990743 [Salmonella enterica subsp. enterica serovar Uganda]
MMFTEWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSVQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT271039 WP_000855694.1 NZ_CP117388:c991557-991267 [Salmonella enterica subsp. enterica serovar Uganda]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A3V8SJE7

References