248132

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 979600..980414 Replicon chromosome
Accession NZ_CP098831
Organism Salmonella enterica subsp. enterica serovar Indiana strain YZ20MCS14

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A4Y6MAM1
Locus tag NFH10_RS04675 Protein ID WP_023227563.1
Coordinates 979600..980127 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID A0A4Y6M833
Locus tag NFH10_RS04680 Protein ID WP_072162154.1
Coordinates 980124..980414 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFH10_RS04650 (975901) 975901..976299 + 399 Protein_912 cytoplasmic protein -
NFH10_RS04655 (976885) 976885..977553 + 669 WP_000445914.1 hypothetical protein -
NFH10_RS04660 (977580) 977580..978074 + 495 WP_023227564.1 hypothetical protein -
NFH10_RS04665 (978319) 978319..978975 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
NFH10_RS04670 (979310) 979310..979527 + 218 Protein_916 IS5/IS1182 family transposase -
NFH10_RS04675 (979600) 979600..980127 - 528 WP_023227563.1 GNAT family N-acetyltransferase Toxin
NFH10_RS04680 (980124) 980124..980414 - 291 WP_072162154.1 DUF1778 domain-containing protein Antitoxin
NFH10_RS04685 (980684) 980684..980862 - 179 Protein_919 IS3 family transposase -
NFH10_RS04690 (981103) 981103..981429 + 327 WP_000393302.1 hypothetical protein -
NFH10_RS04695 (981702) 981702..982049 - 348 WP_001669174.1 DUF1493 family protein -
NFH10_RS04700 (982034) 982034..982483 - 450 WP_000381610.1 membrane protein -
NFH10_RS04705 (982914) 982914..983357 - 444 WP_000715096.1 SPI-1 type III secretion system invasion lipoprotein InvH -
NFH10_RS04710 (983813) 983813..984463 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 979387..989776 10389
- flank IS/Tn - - 979387..979527 140


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19099.93 Da        Isoelectric Point: 9.6420

>T248132 WP_023227563.1 NZ_CP098831:c980127-979600 [Salmonella enterica subsp. enterica serovar Indiana]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGSVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.54 Da        Isoelectric Point: 8.5779

>AT248132 WP_072162154.1 NZ_CP098831:c980414-980124 [Salmonella enterica subsp. enterica serovar Indiana]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Y6MAM1

Antitoxin

Source ID Structure
AlphaFold DB A0A4Y6M833

References