Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1014056..1014870 Replicon chromosome
Accession NZ_CP121073
Organism Salmonella enterica subsp. enterica serovar Infantis strain R22.2169

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A5T8FHB0
Locus tag P8I07_RS04840 Protein ID WP_023994249.1
Coordinates 1014056..1014583 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag P8I07_RS04845 Protein ID WP_000855694.1
Coordinates 1014580..1014870 (-) Length 97 a.a.

Genomic Context

P8I07_RS04825P8I07_RS04835P8I07_RS04855P8I07_RS04875P8I07_RS04820P8I07_RS04830P8I07_RS04840P8I07_RS04845P8I07_RS04850P8I07_RS04860P8I07_RS04865P8I07_RS04870
Location: 1012083..1012604 (522 bp)
Type: Others
Protein ID: WP_023994250.1
Location: 1013766..1013983 (218 bp)
Type: Others
Protein ID: Protein_946
Location: 1015559..1015885 (327 bp)
Type: Others
Protein ID: WP_000393300.1
Location: 1018270..1018920 (651 bp)
Type: Others
Protein ID: WP_001728903.1
Location: 1009357..1011924 (2568 bp)
Type: Others
Protein ID: WP_001005807.1
Location: 1012775..1013431 (657 bp)
Type: Others
Protein ID: WP_000420451.1
Location: 1014056..1014583 (528 bp)
Type: Toxin
Protein ID: WP_023994249.1
Location: 1014580..1014870 (291 bp)
Type: Antitoxin
Protein ID: WP_000855694.1
Location: 1015140..1015318 (179 bp)
Type: Others
Protein ID: Protein_949
Location: 1016158..1016505 (348 bp)
Type: Others
Protein ID: WP_001669174.1
Location: 1016490..1016939 (450 bp)
Type: Others
Protein ID: WP_000381612.1
Location: 1017371..1017814 (444 bp)
Type: Others
Protein ID: WP_023993678.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
P8I07_RS04820 (1009357)1009357..1011924-2568WP_001005807.1DNA mismatch repair protein MutS-
P8I07_RS04825 (1012083)1012083..1012604+522WP_023994250.1hypothetical protein-
P8I07_RS04830 (1012775)1012775..1013431-657WP_000420451.1protein-serine/threonine phosphatase-
P8I07_RS04835 (1013766)1013766..1013983+218Protein_946IS5/IS1182 family transposase-
P8I07_RS04840 (1014056)1014056..1014583-528WP_023994249.1GNAT family N-acetyltransferaseToxin
P8I07_RS04845 (1014580)1014580..1014870-291WP_000855694.1DUF1778 domain-containing proteinAntitoxin
P8I07_RS04850 (1015140)1015140..1015318-179Protein_949IS3 family transposase-
P8I07_RS04855 (1015559)1015559..1015885+327WP_000393300.1hypothetical protein-
P8I07_RS04860 (1016158)1016158..1016505-348WP_001669174.1DUF1493 family protein-
P8I07_RS04865 (1016490)1016490..1016939-450WP_000381612.1membrane protein-
P8I07_RS04870 (1017371)1017371..1017814-444WP_023993678.1SPI-1 type III secretion system invasion lipoprotein InvH-
P8I07_RS04875 (1018270)1018270..1018920+651WP_001728903.1type III secretion system transcriptional activator InvF-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideGenomic island-invH / invF / invG / invE / invA / invB1013843..102423310390
-flankIS/Tn--1013843..1013983140


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19025.89 Da        Isoelectric Point: 9.6423

>T275599 WP_023994249.1 NZ_CP121073:c1014583-1014056 [Salmonella enterica subsp. enterica serovar Infantis]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHALQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNNQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT275599 WP_000855694.1 NZ_CP121073:c1014870-1014580 [Salmonella enterica subsp. enterica serovar Infantis]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A5T8FHB0

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A3V8SJE7

References