Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
Location | 1014056..1014870 | Replicon | chromosome |
Accession | NZ_CP121073 | ||
Organism | Salmonella enterica subsp. enterica serovar Infantis strain R22.2169 |
Toxin (Protein)
Gene name | TacT3 | Uniprot ID | A0A5T8FHB0 |
Locus tag | P8I07_RS04840 | Protein ID | WP_023994249.1 |
Coordinates | 1014056..1014583 (-) | Length | 176 a.a. |
Antitoxin (Protein)
Gene name | TacA3 | Uniprot ID | M7S6I2 |
Locus tag | P8I07_RS04845 | Protein ID | WP_000855694.1 |
Coordinates | 1014580..1014870 (-) | Length | 97 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
P8I07_RS04820 (1009357) | 1009357..1011924 | - | 2568 | WP_001005807.1 | DNA mismatch repair protein MutS | - |
P8I07_RS04825 (1012083) | 1012083..1012604 | + | 522 | WP_023994250.1 | hypothetical protein | - |
P8I07_RS04830 (1012775) | 1012775..1013431 | - | 657 | WP_000420451.1 | protein-serine/threonine phosphatase | - |
P8I07_RS04835 (1013766) | 1013766..1013983 | + | 218 | Protein_946 | IS5/IS1182 family transposase | - |
P8I07_RS04840 (1014056) | 1014056..1014583 | - | 528 | WP_023994249.1 | GNAT family N-acetyltransferase | Toxin |
P8I07_RS04845 (1014580) | 1014580..1014870 | - | 291 | WP_000855694.1 | DUF1778 domain-containing protein | Antitoxin |
P8I07_RS04850 (1015140) | 1015140..1015318 | - | 179 | Protein_949 | IS3 family transposase | - |
P8I07_RS04855 (1015559) | 1015559..1015885 | + | 327 | WP_000393300.1 | hypothetical protein | - |
P8I07_RS04860 (1016158) | 1016158..1016505 | - | 348 | WP_001669174.1 | DUF1493 family protein | - |
P8I07_RS04865 (1016490) | 1016490..1016939 | - | 450 | WP_000381612.1 | membrane protein | - |
P8I07_RS04870 (1017371) | 1017371..1017814 | - | 444 | WP_023993678.1 | SPI-1 type III secretion system invasion lipoprotein InvH | - |
P8I07_RS04875 (1018270) | 1018270..1018920 | + | 651 | WP_001728903.1 | type III secretion system transcriptional activator InvF | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Genomic island | - | invH / invF / invG / invE / invA / invB | 1013843..1024233 | 10390 | ||
- | flank | IS/Tn | - | - | 1013843..1013983 | 140 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 176 a.a. Molecular weight: 19025.89 Da Isoelectric Point: 9.6423
>T275599 WP_023994249.1 NZ_CP121073:c1014583-1014056 [Salmonella enterica subsp. enterica serovar Infantis]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHALQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNNQPLSLLL
SFKTLYAALSASGRL
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHALQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNNQPLSLLL
SFKTLYAALSASGRL
Download Length: 528 bp
Antitoxin
Download Length: 97 a.a. Molecular weight: 10664.50 Da Isoelectric Point: 6.3133
>AT275599 WP_000855694.1 NZ_CP121073:c1014870-1014580 [Salmonella enterica subsp. enterica serovar Infantis]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK
Download Length: 291 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A5T8FHB0 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A3V8SJE7 |