252877

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4111456..4112270 Replicon chromosome
Accession NZ_CP101907
Organism Salmonella enterica subsp. enterica strain QA-1986 973

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A7U1KVS1
Locus tag NP441_RS20160 Protein ID WP_058653211.1
Coordinates 4111456..4111983 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag NP441_RS20165 Protein ID WP_000855694.1
Coordinates 4111980..4112270 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP441_RS20130 (4107658) 4107658..4108056 + 399 Protein_3919 cytoplasmic protein -
NP441_RS20135 (4108247) 4108247..4108486 + 240 Protein_3920 hypothetical protein -
NP441_RS20140 (4108643) 4108643..4109311 + 669 WP_000445914.1 hypothetical protein -
NP441_RS20145 (4109338) 4109338..4109832 + 495 WP_000424947.1 hypothetical protein -
NP441_RS20150 (4110077) 4110077..4110733 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
NP441_RS20155 (4110963) 4110963..4111383 + 421 Protein_3924 IS5 family transposase -
NP441_RS20160 (4111456) 4111456..4111983 - 528 WP_058653211.1 GNAT family N-acetyltransferase Toxin
NP441_RS20165 (4111980) 4111980..4112270 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
NP441_RS20170 (4112540) 4112540..4112718 - 179 Protein_3927 IS3 family transposase -
NP441_RS20175 (4112959) 4112959..4113285 + 327 WP_000393302.1 hypothetical protein -
NP441_RS20180 (4113558) 4113558..4113905 - 348 WP_001669174.1 DUF1493 family protein -
NP441_RS20185 (4113890) 4113890..4114339 - 450 WP_000381617.1 hypothetical protein -
NP441_RS20190 (4114771) 4114771..4115214 - 444 WP_001522905.1 SPI-1 type III secretion system invasion lipoprotein InvH -
NP441_RS20195 (4115670) 4115670..4116320 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 4111189..4121633 10444
- flank IS/Tn - - 4111189..4111383 194


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19051.87 Da        Isoelectric Point: 9.6420

>T252877 WP_058653211.1 NZ_CP101907:c4111983-4111456 [Salmonella enterica subsp. enterica]
MMFTDWHEAAIGKTHNRINFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT252877 WP_000855694.1 NZ_CP101907:c4112270-4111980 [Salmonella enterica subsp. enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U1KVS1

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References