Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1042483..1043297 Replicon chromosome
Accession NZ_CP039502
Organism Salmonella enterica subsp. enterica serovar Bareilly str. CFSAN000189

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag SEEB0189_RS05455 Protein ID WP_000971655.1
Coordinates 1042483..1043010 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag SEEB0189_RS05460 Protein ID WP_000855694.1
Coordinates 1043007..1043297 (-) Length 97 a.a.

Genomic Context

SEEB0189_RS05425SEEB0189_RS05430SEEB0189_RS05435SEEB0189_RS05440SEEB0189_RS05450SEEB0189_RS05470SEEB0189_RS05490SEEB0189_RS05445SEEB0189_RS05455SEEB0189_RS05460SEEB0189_RS05465SEEB0189_RS05475SEEB0189_RS05480SEEB0189_RS05485
Location: 1038767..1039165 (399 bp)
Type: Others
Protein ID: Protein_978
Location: 1039376..1039594 (219 bp)
Type: Others
Protein ID: Protein_979
Location: 1039751..1040419 (669 bp)
Type: Others
Protein ID: WP_000445914.1
Location: 1040446..1040940 (495 bp)
Type: Others
Protein ID: WP_000424947.1
Location: 1042000..1042410 (411 bp)
Type: Others
Protein ID: Protein_983
Location: 1043997..1044323 (327 bp)
Type: Others
Protein ID: WP_000393302.1
Location: 1046708..1047358 (651 bp)
Type: Others
Protein ID: WP_001674874.1
Location: 1041111..1041767 (657 bp)
Type: Others
Protein ID: WP_020839120.1
Location: 1042483..1043010 (528 bp)
Type: Toxin
Protein ID: WP_000971655.1
Location: 1043007..1043297 (291 bp)
Type: Antitoxin
Protein ID: WP_000855694.1
Location: 1043567..1043756 (190 bp)
Type: Others
Protein ID: Protein_986
Location: 1044596..1044943 (348 bp)
Type: Others
Protein ID: WP_001669174.1
Location: 1044928..1045377 (450 bp)
Type: Others
Protein ID: WP_000381612.1
Location: 1045809..1046252 (444 bp)
Type: Others
Protein ID: WP_000715096.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
SEEB0189_RS05425 (1038767)1038767..1039165+399Protein_978cytoplasmic protein-
SEEB0189_RS05430 (1039376)1039376..1039594+219Protein_979hypothetical protein-
SEEB0189_RS05435 (1039751)1039751..1040419+669WP_000445914.1hypothetical protein-
SEEB0189_RS05440 (1040446)1040446..1040940+495WP_000424947.1hypothetical protein-
SEEB0189_RS05445 (1041111)1041111..1041767-657WP_020839120.1protein-serine/threonine phosphatase-
SEEB0189_RS05450 (1042000)1042000..1042410+411Protein_983IS5/IS1182 family transposase-
SEEB0189_RS05455 (1042483)1042483..1043010-528WP_000971655.1GNAT family N-acetyltransferaseToxin
SEEB0189_RS05460 (1043007)1043007..1043297-291WP_000855694.1DUF1778 domain-containing proteinAntitoxin
SEEB0189_RS05465 (1043567)1043567..1043756-190Protein_986IS3 family transposase-
SEEB0189_RS05470 (1043997)1043997..1044323+327WP_000393302.1hypothetical protein-
SEEB0189_RS05475 (1044596)1044596..1044943-348WP_001669174.1DUF1493 family protein-
SEEB0189_RS05480 (1044928)1044928..1045377-450WP_000381612.1membrane protein-
SEEB0189_RS05485 (1045809)1045809..1046252-444WP_000715096.1SPI-1 type III secretion system invasion lipoprotein InvH-
SEEB0189_RS05490 (1046708)1046708..1047358+651WP_001674874.1type III secretion system transcriptional activator InvF-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideGenomic island-invH / invF / invG / invE / invA / invB1042186..105267110485
-flankIS/Tn--1042186..1042410224


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T124046 WP_000971655.1 NZ_CP039502:c1043010-1042483 [Salmonella enterica subsp. enterica serovar Bareilly str.]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T124046 NZ_CP039502:c1043010-1042483 [Salmonella enterica subsp. enterica serovar Bareilly str.]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGCGGCGTAGCCCTGCTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT124046 WP_000855694.1 NZ_CP039502:c1043297-1043007 [Salmonella enterica subsp. enterica serovar Bareilly str.]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT124046 NZ_CP039502:c1043297-1043007 [Salmonella enterica subsp. enterica serovar Bareilly str.]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGTGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCTGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB6G96
PDB7AK9

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A3V8SJE7

References