124046

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1042483..1043297 Replicon chromosome
Accession NZ_CP039502
Organism Salmonella enterica subsp. enterica serovar Bareilly str. CFSAN000189

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag SEEB0189_RS05455 Protein ID WP_000971655.1
Coordinates 1042483..1043010 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag SEEB0189_RS05460 Protein ID WP_000855694.1
Coordinates 1043007..1043297 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SEEB0189_RS05425 (1038767) 1038767..1039165 + 399 Protein_978 cytoplasmic protein -
SEEB0189_RS05430 (1039376) 1039376..1039594 + 219 Protein_979 hypothetical protein -
SEEB0189_RS05435 (1039751) 1039751..1040419 + 669 WP_000445914.1 hypothetical protein -
SEEB0189_RS05440 (1040446) 1040446..1040940 + 495 WP_000424947.1 hypothetical protein -
SEEB0189_RS05445 (1041111) 1041111..1041767 - 657 WP_020839120.1 protein-serine/threonine phosphatase -
SEEB0189_RS05450 (1042000) 1042000..1042410 + 411 Protein_983 IS5/IS1182 family transposase -
SEEB0189_RS05455 (1042483) 1042483..1043010 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
SEEB0189_RS05460 (1043007) 1043007..1043297 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
SEEB0189_RS05465 (1043567) 1043567..1043756 - 190 Protein_986 IS3 family transposase -
SEEB0189_RS05470 (1043997) 1043997..1044323 + 327 WP_000393302.1 hypothetical protein -
SEEB0189_RS05475 (1044596) 1044596..1044943 - 348 WP_001669174.1 DUF1493 family protein -
SEEB0189_RS05480 (1044928) 1044928..1045377 - 450 WP_000381612.1 membrane protein -
SEEB0189_RS05485 (1045809) 1045809..1046252 - 444 WP_000715096.1 SPI-1 type III secretion system invasion lipoprotein InvH -
SEEB0189_RS05490 (1046708) 1046708..1047358 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 1042186..1052671 10485
- flank IS/Tn - - 1042186..1042410 224


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T124046 WP_000971655.1 NZ_CP039502:c1043010-1042483 [Salmonella enterica subsp. enterica serovar Bareilly str.]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T124046 NZ_CP039502:c1043010-1042483 [Salmonella enterica subsp. enterica serovar Bareilly str.]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGCGGCGTAGCCCTGCTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT124046 WP_000855694.1 NZ_CP039502:c1043297-1043007 [Salmonella enterica subsp. enterica serovar Bareilly str.]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT124046 NZ_CP039502:c1043297-1043007 [Salmonella enterica subsp. enterica serovar Bareilly str.]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGTGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCTGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References