Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 990873..991687 Replicon chromosome
Accession NZ_CP117384
Organism Salmonella enterica subsp. enterica serovar Uganda strain RM013

Toxin (Protein)


Gene name TacT3 Uniprot ID -
Locus tag PQP89_RS04810 Protein ID WP_000971658.1
Coordinates 990873..991400 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag PQP89_RS04815 Protein ID WP_000855694.1
Coordinates 991397..991687 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP89_RS04780 (987084) 987084..987481 + 398 Protein_935 cytoplasmic protein -
PQP89_RS04785 (987672) 987672..987860 + 189 Protein_936 hypothetical protein -
PQP89_RS04790 (988068) 988068..988736 + 669 WP_000445914.1 hypothetical protein -
PQP89_RS04795 (988763) 988763..989257 + 495 WP_000424948.1 hypothetical protein -
PQP89_RS04800 (989502) 989502..990158 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
PQP89_RS04805 (990391) 990391..990800 + 410 Protein_940 IS5/IS1182 family transposase -
PQP89_RS04810 (990873) 990873..991400 - 528 WP_000971658.1 GNAT family N-acetyltransferase Toxin
PQP89_RS04815 (991397) 991397..991687 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
PQP89_RS04820 (991957) 991957..992157 - 201 Protein_943 IS3 family transposase -
PQP89_RS04825 (992398) 992398..992724 + 327 WP_000393305.1 hypothetical protein -
PQP89_RS04830 (992997) 992997..993344 - 348 WP_001669174.1 DUF1493 family protein -
PQP89_RS04835 (993329) 993329..993778 - 450 WP_000381612.1 membrane protein -
PQP89_RS04840 (994210) 994210..994653 - 444 WP_079798511.1 SPI-1 type III secretion system invasion lipoprotein InvH -
PQP89_RS04845 (995109) 995109..995759 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 990660..1001072 10412
- flank IS/Tn - - 990660..990800 140


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19051.87 Da        Isoelectric Point: 9.6420

>T270995 WP_000971658.1 NZ_CP117384:c991400-990873 [Salmonella enterica subsp. enterica serovar Uganda]
MMFTEWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSVQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT270995 WP_000855694.1 NZ_CP117384:c991687-991397 [Salmonella enterica subsp. enterica serovar Uganda]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References