256669

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1007685..1008499 Replicon chromosome
Accession NZ_CP103791
Organism Salmonella enterica subsp. enterica serovar Infantis strain MRS17_00712

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A5T8FHB0
Locus tag NYQ90_RS04815 Protein ID WP_023994249.1
Coordinates 1007685..1008212 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag NYQ90_RS04820 Protein ID WP_000855694.1
Coordinates 1008209..1008499 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYQ90_RS04795 (1002986) 1002986..1005553 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
NYQ90_RS04800 (1005712) 1005712..1006233 + 522 WP_023994250.1 hypothetical protein -
NYQ90_RS04805 (1006404) 1006404..1007060 - 657 WP_000420451.1 protein-serine/threonine phosphatase -
NYQ90_RS04810 (1007395) 1007395..1007612 + 218 Protein_941 IS5/IS1182 family transposase -
NYQ90_RS04815 (1007685) 1007685..1008212 - 528 WP_023994249.1 GNAT family N-acetyltransferase Toxin
NYQ90_RS04820 (1008209) 1008209..1008499 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
NYQ90_RS04825 (1008769) 1008769..1008947 - 179 Protein_944 IS3 family transposase -
NYQ90_RS04830 (1009188) 1009188..1009514 + 327 WP_000393300.1 hypothetical protein -
NYQ90_RS04835 (1009787) 1009787..1010134 - 348 WP_001669174.1 DUF1493 family protein -
NYQ90_RS04840 (1010119) 1010119..1010568 - 450 WP_000381612.1 membrane protein -
NYQ90_RS04845 (1011000) 1011000..1011443 - 444 WP_023993678.1 SPI-1 type III secretion system invasion lipoprotein InvH -
NYQ90_RS04850 (1011899) 1011899..1012549 + 651 WP_001728903.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 1007472..1017862 10390
- flank IS/Tn - - 1007472..1007612 140


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19025.89 Da        Isoelectric Point: 9.6423

>T256669 WP_023994249.1 NZ_CP103791:c1008212-1007685 [Salmonella enterica subsp. enterica serovar Infantis]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHALQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNNQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT256669 WP_000855694.1 NZ_CP103791:c1008499-1008209 [Salmonella enterica subsp. enterica serovar Infantis]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5T8FHB0

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References