Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 990613..991427 Replicon chromosome
Accession NZ_CP117394
Organism Salmonella enterica subsp. enterica serovar Uganda strain RM017

Toxin (Protein)


Gene name TacT3 Uniprot ID -
Locus tag PQP77_RS04810 Protein ID WP_000971658.1
Coordinates 990613..991140 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag PQP77_RS04815 Protein ID WP_000855694.1
Coordinates 991137..991427 (-) Length 97 a.a.

Genomic Context

PQP77_RS04780PQP77_RS04785PQP77_RS04790PQP77_RS04795PQP77_RS04805PQP77_RS04825PQP77_RS04845PQP77_RS04800PQP77_RS04810PQP77_RS04815PQP77_RS04820PQP77_RS04830PQP77_RS04835PQP77_RS04840
Location: 986824..987221 (398 bp)
Type: Others
Protein ID: Protein_935
Location: 987412..987600 (189 bp)
Type: Others
Protein ID: Protein_936
Location: 987808..988476 (669 bp)
Type: Others
Protein ID: WP_000445914.1
Location: 988503..988997 (495 bp)
Type: Others
Protein ID: WP_000424948.1
Location: 990131..990540 (410 bp)
Type: Others
Protein ID: Protein_940
Location: 992138..992464 (327 bp)
Type: Others
Protein ID: WP_000393305.1
Location: 994849..995499 (651 bp)
Type: Others
Protein ID: WP_001674874.1
Location: 989242..989898 (657 bp)
Type: Others
Protein ID: WP_000420452.1
Location: 990613..991140 (528 bp)
Type: Toxin
Protein ID: WP_000971658.1
Location: 991137..991427 (291 bp)
Type: Antitoxin
Protein ID: WP_000855694.1
Location: 991697..991897 (201 bp)
Type: Others
Protein ID: Protein_943
Location: 992737..993084 (348 bp)
Type: Others
Protein ID: WP_001669174.1
Location: 993069..993518 (450 bp)
Type: Others
Protein ID: WP_000381612.1
Location: 993950..994393 (444 bp)
Type: Others
Protein ID: WP_079798511.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
PQP77_RS04780 (986824)986824..987221+398Protein_935cytoplasmic protein-
PQP77_RS04785 (987412)987412..987600+189Protein_936hypothetical protein-
PQP77_RS04790 (987808)987808..988476+669WP_000445914.1hypothetical protein-
PQP77_RS04795 (988503)988503..988997+495WP_000424948.1hypothetical protein-
PQP77_RS04800 (989242)989242..989898-657WP_000420452.1protein-serine/threonine phosphatase-
PQP77_RS04805 (990131)990131..990540+410Protein_940IS5/IS1182 family transposase-
PQP77_RS04810 (990613)990613..991140-528WP_000971658.1GNAT family N-acetyltransferaseToxin
PQP77_RS04815 (991137)991137..991427-291WP_000855694.1DUF1778 domain-containing proteinAntitoxin
PQP77_RS04820 (991697)991697..991897-201Protein_943IS3 family transposase-
PQP77_RS04825 (992138)992138..992464+327WP_000393305.1hypothetical protein-
PQP77_RS04830 (992737)992737..993084-348WP_001669174.1DUF1493 family protein-
PQP77_RS04835 (993069)993069..993518-450WP_000381612.1membrane protein-
PQP77_RS04840 (993950)993950..994393-444WP_079798511.1SPI-1 type III secretion system invasion lipoprotein InvH-
PQP77_RS04845 (994849)994849..995499+651WP_001674874.1type III secretion system transcriptional activator InvF-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideGenomic island-invH / invF / invG / invE / invA / invB990400..100081210412
-flankIS/Tn--990400..990540140


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19051.87 Da        Isoelectric Point: 9.6420

>T271096 WP_000971658.1 NZ_CP117394:c991140-990613 [Salmonella enterica subsp. enterica serovar Uganda]
MMFTEWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSVQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT271096 WP_000855694.1 NZ_CP117394:c991427-991137 [Salmonella enterica subsp. enterica serovar Uganda]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A3V8SJE7

References