Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
Location | 1028325..1029139 | Replicon | chromosome |
Accession | NZ_CP126325 | ||
Organism | Salmonella enterica subsp. enterica strain HL21 |
Toxin (Protein)
Gene name | TacT3 | Uniprot ID | M7RPS8 |
Locus tag | QN088_RS04910 | Protein ID | WP_000971649.1 |
Coordinates | 1028325..1028852 (-) | Length | 176 a.a. |
Antitoxin (Protein)
Gene name | TacA3 | Uniprot ID | M7S6I2 |
Locus tag | QN088_RS04915 | Protein ID | WP_000855694.1 |
Coordinates | 1028849..1029139 (-) | Length | 97 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
QN088_RS04885 (1024535) | 1024535..1024933 | + | 399 | Protein_957 | cytoplasmic protein | - |
QN088_RS04890 (1025519) | 1025519..1026187 | + | 669 | WP_023244864.1 | hypothetical protein | - |
QN088_RS04895 (1026214) | 1026214..1026708 | + | 495 | WP_000424942.1 | hypothetical protein | - |
QN088_RS04900 (1026953) | 1026953..1027609 | - | 657 | WP_001748710.1 | protein-serine/threonine phosphatase | - |
QN088_RS04905 (1027842) | 1027842..1028252 | + | 411 | Protein_961 | IS5/IS1182 family transposase | - |
QN088_RS04910 (1028325) | 1028325..1028852 | - | 528 | WP_000971649.1 | GNAT family N-acetyltransferase | Toxin |
QN088_RS04915 (1028849) | 1028849..1029139 | - | 291 | WP_000855694.1 | DUF1778 domain-containing protein | Antitoxin |
QN088_RS04920 (1029409) | 1029409..1029587 | - | 179 | Protein_964 | IS3 family transposase | - |
QN088_RS04925 (1029828) | 1029828..1030154 | + | 327 | WP_000393300.1 | hypothetical protein | - |
QN088_RS04930 (1030427) | 1030427..1030774 | - | 348 | WP_001669174.1 | DUF1493 family protein | - |
QN088_RS04935 (1030759) | 1030759..1031208 | - | 450 | WP_284546217.1 | hypothetical protein | - |
QN088_RS04940 (1031640) | 1031640..1032083 | - | 444 | WP_000715096.1 | SPI-1 type III secretion system invasion lipoprotein InvH | - |
QN088_RS04945 (1032540) | 1032540..1033190 | + | 651 | WP_001674874.1 | type III secretion system transcriptional activator InvF | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Genomic island | - | invH / invF / invG / invE / invA / invB | 1028028..1038503 | 10475 | ||
- | flank | IS/Tn | - | - | 1028028..1028252 | 224 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 176 a.a. Molecular weight: 19026.88 Da Isoelectric Point: 9.3905
>T282769 WP_000971649.1 NZ_CP126325:c1028852-1028325 [Salmonella enterica subsp. enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHALQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHALQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL
Download Length: 528 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A3V5VVF5 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A3V8SJE7 |