Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1028325..1029139 Replicon chromosome
Accession NZ_CP126325
Organism Salmonella enterica subsp. enterica strain HL21

Toxin (Protein)


Gene name TacT3 Uniprot ID M7RPS8
Locus tag QN088_RS04910 Protein ID WP_000971649.1
Coordinates 1028325..1028852 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag QN088_RS04915 Protein ID WP_000855694.1
Coordinates 1028849..1029139 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN088_RS04885 (1024535) 1024535..1024933 + 399 Protein_957 cytoplasmic protein -
QN088_RS04890 (1025519) 1025519..1026187 + 669 WP_023244864.1 hypothetical protein -
QN088_RS04895 (1026214) 1026214..1026708 + 495 WP_000424942.1 hypothetical protein -
QN088_RS04900 (1026953) 1026953..1027609 - 657 WP_001748710.1 protein-serine/threonine phosphatase -
QN088_RS04905 (1027842) 1027842..1028252 + 411 Protein_961 IS5/IS1182 family transposase -
QN088_RS04910 (1028325) 1028325..1028852 - 528 WP_000971649.1 GNAT family N-acetyltransferase Toxin
QN088_RS04915 (1028849) 1028849..1029139 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
QN088_RS04920 (1029409) 1029409..1029587 - 179 Protein_964 IS3 family transposase -
QN088_RS04925 (1029828) 1029828..1030154 + 327 WP_000393300.1 hypothetical protein -
QN088_RS04930 (1030427) 1030427..1030774 - 348 WP_001669174.1 DUF1493 family protein -
QN088_RS04935 (1030759) 1030759..1031208 - 450 WP_284546217.1 hypothetical protein -
QN088_RS04940 (1031640) 1031640..1032083 - 444 WP_000715096.1 SPI-1 type III secretion system invasion lipoprotein InvH -
QN088_RS04945 (1032540) 1032540..1033190 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 1028028..1038503 10475
- flank IS/Tn - - 1028028..1028252 224


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19026.88 Da        Isoelectric Point: 9.3905

>T282769 WP_000971649.1 NZ_CP126325:c1028852-1028325 [Salmonella enterica subsp. enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHALQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT282769 WP_000855694.1 NZ_CP126325:c1029139-1028849 [Salmonella enterica subsp. enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V5VVF5

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References