Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
Location | 1063046..1063860 | Replicon | chromosome |
Accession | NZ_CP089313 | ||
Organism | Salmonella enterica subsp. enterica serovar Indiana strain YZ21MCS4 |
Toxin (Protein)
Gene name | TacT3 | Uniprot ID | A0A4Y6MAM1 |
Locus tag | LT987_RS05215 | Protein ID | WP_023227563.1 |
Coordinates | 1063046..1063573 (-) | Length | 176 a.a. |
Antitoxin (Protein)
Gene name | TacA3 | Uniprot ID | A0A4Y6M833 |
Locus tag | LT987_RS05220 | Protein ID | WP_072162154.1 |
Coordinates | 1063570..1063860 (-) | Length | 97 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LT987_RS05190 (1059347) | 1059347..1059745 | + | 399 | Protein_1020 | cytoplasmic protein | - |
LT987_RS05195 (1060331) | 1060331..1060999 | + | 669 | WP_000445914.1 | hypothetical protein | - |
LT987_RS05200 (1061026) | 1061026..1061520 | + | 495 | WP_023227564.1 | hypothetical protein | - |
LT987_RS05205 (1061765) | 1061765..1062421 | - | 657 | WP_000420452.1 | protein-serine/threonine phosphatase | - |
LT987_RS05210 (1062756) | 1062756..1062973 | + | 218 | Protein_1024 | IS5/IS1182 family transposase | - |
LT987_RS05215 (1063046) | 1063046..1063573 | - | 528 | WP_023227563.1 | GNAT family N-acetyltransferase | Toxin |
LT987_RS05220 (1063570) | 1063570..1063860 | - | 291 | WP_072162154.1 | DUF1778 domain-containing protein | Antitoxin |
LT987_RS05225 (1064130) | 1064130..1064308 | - | 179 | Protein_1027 | IS3 family transposase | - |
LT987_RS05230 (1064549) | 1064549..1064875 | + | 327 | WP_000393302.1 | hypothetical protein | - |
LT987_RS05235 (1065148) | 1065148..1065495 | - | 348 | WP_001669174.1 | DUF1493 family protein | - |
LT987_RS05240 (1065480) | 1065480..1065929 | - | 450 | WP_000381610.1 | membrane protein | - |
LT987_RS05245 (1066360) | 1066360..1066803 | - | 444 | WP_000715096.1 | SPI-1 type III secretion system invasion lipoprotein InvH | - |
LT987_RS05250 (1067259) | 1067259..1067909 | + | 651 | WP_001674874.1 | type III secretion system transcriptional activator InvF | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Genomic island | - | invH / invF / invG / invE / invA / invB | 1062833..1073222 | 10389 | ||
- | flank | IS/Tn | - | - | 1062833..1062973 | 140 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 176 a.a. Molecular weight: 19099.93 Da Isoelectric Point: 9.6420
>T228027 WP_023227563.1 NZ_CP089313:c1063573-1063046 [Salmonella enterica subsp. enterica serovar Indiana]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGSVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGSVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL
Download Length: 528 bp
>T228027 NZ_CP123257:79099-79248 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA
Antitoxin
Download Length: 97 a.a. Molecular weight: 10664.54 Da Isoelectric Point: 8.5779
>AT228027 WP_072162154.1 NZ_CP089313:c1063860-1063570 [Salmonella enterica subsp. enterica serovar Indiana]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK
Download Length: 291 bp
>AT228027 NZ_CP123257:c79054-78995 [Escherichia coli]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A4Y6MAM1 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A4Y6M833 |