Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1063046..1063860 Replicon chromosome
Accession NZ_CP089313
Organism Salmonella enterica subsp. enterica serovar Indiana strain YZ21MCS4

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A4Y6MAM1
Locus tag LT987_RS05215 Protein ID WP_023227563.1
Coordinates 1063046..1063573 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID A0A4Y6M833
Locus tag LT987_RS05220 Protein ID WP_072162154.1
Coordinates 1063570..1063860 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LT987_RS05190 (1059347) 1059347..1059745 + 399 Protein_1020 cytoplasmic protein -
LT987_RS05195 (1060331) 1060331..1060999 + 669 WP_000445914.1 hypothetical protein -
LT987_RS05200 (1061026) 1061026..1061520 + 495 WP_023227564.1 hypothetical protein -
LT987_RS05205 (1061765) 1061765..1062421 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
LT987_RS05210 (1062756) 1062756..1062973 + 218 Protein_1024 IS5/IS1182 family transposase -
LT987_RS05215 (1063046) 1063046..1063573 - 528 WP_023227563.1 GNAT family N-acetyltransferase Toxin
LT987_RS05220 (1063570) 1063570..1063860 - 291 WP_072162154.1 DUF1778 domain-containing protein Antitoxin
LT987_RS05225 (1064130) 1064130..1064308 - 179 Protein_1027 IS3 family transposase -
LT987_RS05230 (1064549) 1064549..1064875 + 327 WP_000393302.1 hypothetical protein -
LT987_RS05235 (1065148) 1065148..1065495 - 348 WP_001669174.1 DUF1493 family protein -
LT987_RS05240 (1065480) 1065480..1065929 - 450 WP_000381610.1 membrane protein -
LT987_RS05245 (1066360) 1066360..1066803 - 444 WP_000715096.1 SPI-1 type III secretion system invasion lipoprotein InvH -
LT987_RS05250 (1067259) 1067259..1067909 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 1062833..1073222 10389
- flank IS/Tn - - 1062833..1062973 140


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19099.93 Da        Isoelectric Point: 9.6420

>T228027 WP_023227563.1 NZ_CP089313:c1063573-1063046 [Salmonella enterica subsp. enterica serovar Indiana]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGSVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T228027 NZ_CP123257:79099-79248 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.54 Da        Isoelectric Point: 8.5779

>AT228027 WP_072162154.1 NZ_CP089313:c1063860-1063570 [Salmonella enterica subsp. enterica serovar Indiana]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT228027 NZ_CP123257:c79054-78995 [Escherichia coli]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Y6MAM1

Antitoxin

Source ID Structure
AlphaFold DB A0A4Y6M833

References