Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 1008276..1009090 | Replicon | chromosome |
| Accession | NZ_CP119137 | ||
| Organism | Salmonella enterica subsp. enterica serovar Goldcoast isolate Sal02792 | ||
Toxin (Protein)
| Gene name | TacT3 | Uniprot ID | - |
| Locus tag | P0D85_RS06080 | Protein ID | WP_126523877.1 |
| Coordinates | 1008276..1008803 (-) | Length | 176 a.a. |
Antitoxin (Protein)
| Gene name | TacA3 | Uniprot ID | M7S6I2 |
| Locus tag | P0D85_RS06085 | Protein ID | WP_000855694.1 |
| Coordinates | 1008800..1009090 (-) | Length | 97 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| P0D85_RS06060 (1003576) | 1003576..1006143 | - | 2568 | WP_001005802.1 | DNA mismatch repair protein MutS | - |
| P0D85_RS06065 (1006302) | 1006302..1006823 | + | 522 | WP_061383865.1 | hypothetical protein | - |
| P0D85_RS06070 (1006995) | 1006995..1007651 | - | 657 | WP_058821376.1 | protein-serine/threonine phosphatase | - |
| P0D85_RS06075 (1007986) | 1007986..1008203 | + | 218 | Protein_945 | IS5/IS1182 family transposase | - |
| P0D85_RS06080 (1008276) | 1008276..1008803 | - | 528 | WP_126523877.1 | GNAT family N-acetyltransferase | Toxin |
| P0D85_RS06085 (1008800) | 1008800..1009090 | - | 291 | WP_000855694.1 | DUF1778 domain-containing protein | Antitoxin |
| P0D85_RS06090 (1009360) | 1009360..1009545 | - | 186 | Protein_948 | IS3 family transposase | - |
| P0D85_RS06095 (1009800) | 1009800..1010126 | + | 327 | WP_000393302.1 | hypothetical protein | - |
| P0D85_RS06100 (1010399) | 1010399..1010746 | - | 348 | WP_001669174.1 | DUF1493 family protein | - |
| P0D85_RS06105 (1010731) | 1010731..1011180 | - | 450 | WP_023261375.1 | hypothetical protein | - |
| P0D85_RS06110 (1011611) | 1011611..1012054 | - | 444 | WP_126523878.1 | SPI-1 type III secretion system invasion lipoprotein InvH | - |
| P0D85_RS06115 (1012511) | 1012511..1013161 | + | 651 | WP_001674874.1 | type III secretion system transcriptional activator InvF | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| inside | Genomic island | - | invH / invF / invG / invE / invA / invB | 1006995..1018474 | 11479 | ||
| - | flank | IS/Tn | - | - | 1008063..1008203 | 140 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 176 a.a. Molecular weight: 19097.96 Da Isoelectric Point: 9.6420
>T273820 WP_126523877.1 NZ_CP119137:c1008803-1008276 [Salmonella enterica subsp. enterica serovar Goldcoast]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHVRQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHVRQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL
Download Length: 528 bp
Antitoxin
Download Length: 97 a.a. Molecular weight: 10664.50 Da Isoelectric Point: 6.3133
>AT273820 WP_000855694.1 NZ_CP119137:c1009090-1008800 [Salmonella enterica subsp. enterica serovar Goldcoast]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK
Download Length: 291 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|