297244

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/-
Location 4453380..4454005 Replicon chromosome
Accession UFRD01000002
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain NCTC12023

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NCTC12023_04723 Protein ID SUH99942.1
Coordinates 4453607..4454005 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag NCTC12023_04722 Protein ID SUH99941.1
Coordinates 4453380..4453607 (+) Length 76 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NCTC12023_04715 4448425..4449942 + 1518 SUH99936.1 lysyl tRNA synthetase -
NCTC12023_04716 4450018..4450563 - 546 SUH99937.1 isopentenyl-diphosphate delta-isomerase -
NCTC12023_04718 4450828..4451586 + 759 SUH99938.1 possible lipoprotein -
NCTC12023_04720 4451871..4452671 - 801 SUH99939.1 putative inner membrane protein -
NCTC12023_04721 4452952..4453212 - 261 SUH99940.1 endonuclease -
NCTC12023_04722 4453380..4453607 + 228 SUH99941.1 virulence-associated protein Antitoxin
NCTC12023_04723 4453607..4454005 + 399 SUH99942.1 plasmid maintenance protein Toxin
NCTC12023_04725 4454811..4455347 + 537 SUH99943.1 outer membrane protein (associated with virulence) -
NCTC12023_04726 4455394..4455777 + 384 SUH99944.1 YfdX protein -
NCTC12023_04727 4455774..4456025 + 252 SUH99945.1 YfdX protein -
NCTC12023_04728 4456744..4457328 + 585 SUH99946.1 fimbrial-like protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 4451871..4463194 11323


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-123)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T297244 SUH99942.1 UFRD01000002:4453607-4454005 [Salmonella enterica subsp. enterica serovar Typhimurium]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T297244 UFRD01000002:4453607-4454005 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTTTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCGGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAATTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT297244 SUH99941.1 UFRD01000002:4453380-4453607 [Salmonella enterica subsp. enterica serovar Typhimurium]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT297244 UFRD01000002:4453380-4453607 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGAGGATGTGAA
ACATGTCGAAATCATTGCGGTTGGCAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGTACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTTTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References