Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2744571..2745196 Replicon chromosome
Accession NZ_CP085819
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain Blastoise

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag LJF65_RS13005 Protein ID WP_000911336.1
Coordinates 2744798..2745196 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag LJF65_RS13000 Protein ID WP_000557549.1
Coordinates 2744571..2744798 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF65_RS12970 (2739616) 2739616..2741133 + 1518 WP_000003339.1 lysine--tRNA ligase -
LJF65_RS12975 (2741209) 2741209..2741754 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
LJF65_RS12980 (2742019) 2742019..2742777 + 759 WP_000244329.1 amidase activator ActS -
LJF65_RS12990 (2743062) 2743062..2743868 - 807 WP_010989071.1 DUF1460 domain-containing protein -
LJF65_RS12995 (2744143) 2744143..2744394 - 252 WP_001540858.1 hypothetical protein -
LJF65_RS13000 (2744571) 2744571..2744798 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
LJF65_RS13005 (2744798) 2744798..2745196 + 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
LJF65_RS13010 (2746002) 2746002..2746538 + 537 WP_001038506.1 STM3031 family outer membrane protein -
LJF65_RS13015 (2746585) 2746585..2747217 + 633 WP_000835265.1 YfdX family protein -
LJF65_RS13020 (2747936) 2747936..2748520 + 585 WP_001244638.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2743062..2754391 11329


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T221969 WP_000911336.1 NZ_CP085819:2744798-2745196 [Salmonella enterica subsp. enterica serovar Typhimurium]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T221969 NZ_CP117647:314543-315070 [Escherichia albertii]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTGGTTCGTCAACATCGCAATAAAATTTTGCGAGCGTATATCCTTTGTAGCAACACTC
CAGAACGTCAGGTCCTGGGATATTACACATTATCCGGCAGTTGTTTTGAACGAGCCGCACTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTCACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGAGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCATTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCTCTGAATGAAAAAGCCCATACGTTTTATCAGTCGCTGGGCTTTATCCCGTTGGTTGGAGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATTGAACTGCTTTTTACACAGAGCGATTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT221969 WP_000557549.1 NZ_CP085819:2744571-2744798 [Salmonella enterica subsp. enterica serovar Typhimurium]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT221969 NZ_CP117647:314270-314536 [Escherichia albertii]
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCTGCGAT
ATCTAATCAATCCGTCAGCCAATTTATGTTGAACTGCGCTTCGCAGCGAGCTGCGGAAGTGATTGAACAGAATCGGCGGA
TGATTCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGTTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References