Detailed information of TA system TA025956

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 3215876..3216501
• Accession: NC_016810
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: M7SD17
• Locus tag: SL1344_RS15690
• Protein ID: WP_000911336.1
• Coordinates: 3215876..3216274 (-)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: M7S3S8
• Locus tag: SL1344_RS15695
• Protein ID: WP_000557549.1
• Coordinates: 3216274..3216501 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SL1344_RS15675 (SL1344_3008)	3212552..3213136	-	585	WP_001244638.1	fimbrial protein	-
SL1344_RS15680 (SL1344_3009)	3213855..3214487	-	633	WP_000835265.1	YfdX family protein	-
SL1344_RS15685 (SL1344_3010)	3214534..3215070	-	537	WP_001038506.1	STM3031 family outer membrane protein	-
SL1344_RS15690 (SL1344_3011)	3215876..3216274	-	399	WP_000911336.1	tRNA(fMet)-specific endonuclease VapC	Toxin
SL1344_RS15695 (SL1344_3012)	3216274..3216501	-	228	WP_000557549.1	toxin-antitoxin system antitoxin VapB	Antitoxin
SL1344_RS15700	3216678..3216929	+	252	WP_001540858.1	hypothetical protein	-
SL1344_RS15705 (SL1344_3013)	3217204..3218010	+	807	WP_010989071.1	DUF1460 domain-containing protein	-
SL1344_RS15715 (SL1344_3014)	3218295..3219053	-	759	WP_000244329.1	amidase activator ActS	-
SL1344_RS15720 (SL1344_3015)	3219318..3219863	+	546	WP_000133994.1	isopentenyl-diphosphate Delta-isomerase	-
SL1344_RS15725 (SL1344_3016)	3219939..3221456	-	1518	WP_000003339.1	lysine--tRNA ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_003197 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 Genomic island TA000439 3186004..3197296 0.002 View NC_003197 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 Genomic island TA000439 3186004..3197296 0.002 View UFRD01000002 Salmonella enterica subsp. enterica serovar Typhimurium strain NCTC12023 Genomic island TA297244 4451871..4463194 0.002 View NC_016856 Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S Genomic island TA026056 3205849..3216429 0 View NZ_AP023288 Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-3835 Genomic island TA037173 897307..908632 0.002 View NZ_AP023289 Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-3837 Genomic island TA037197 960525..971850 0.002 View NZ_AP023290 Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-3844 Genomic island TA037221 879784..891109 0.002 View NZ_AP023291 Salmonella enterica subsp. enterica serovar Typhimurium strain L-4126 Genomic island TA037245 847804..859129 0.002 View NZ_AP023292 Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4233 Genomic island TA037269 847808..859133 0.002 View NZ_AP023294 Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4261 Genomic island TA037293 847806..859131 0.002 View NZ_AP023299 Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4334 Genomic island TA037318 847808..859133 0.002 View NZ_AP023300 Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4445 Genomic island TA037342 847808..859133 0.002 View NZ_AP023303 Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4526 Genomic island TA037371 879784..891109 0.002 View NZ_AP023304 Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4551 Genomic island TA037394 881121..892446 0.002 View NZ_AP023306 Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4567 Genomic island TA037419 847808..859133 0.002 View NZ_AP023309 Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4578 Genomic island TA037452 847774..859099 0.002 View NZ_AP023311 Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4596 Genomic island TA037477 847808..857732 0.002 View NZ_AP023313 Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4605 Genomic island TA037501 847804..859129 0.002 View NZ_AP023315 Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4614 Genomic island TA037530 847782..859107 0.002 View NZ_AP023317 Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4681 Genomic island TA037555 880558..891883 0.002 View NZ_AP023319 Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4741 Genomic island TA037580 847808..859133 0.002 View NZ_CP047522 Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF11216 Genomic island TA146346 4050921..4061501 0 View NZ_CP047525 Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF11077 Genomic island TA146361 879809..891134 0.002 View NZ_CP047527 Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10648 Genomic island TA146401 4108832..4119412 0 View NZ_CP047529 Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10640 Genomic island TA146426 4088003..4098583 0 View NZ_CP047531 Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10484 Genomic island TA146436 879484..890809 0.002 View NZ_CP047535 Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10452 Genomic island TA146461 679513..690838 0.002 View NZ_CP047537 Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10405 Genomic island TA146501 4026907..4037487 0 View NZ_CP047542 Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10330 Genomic island TA146556 4108745..4119325 0 View NZ_CP047544 Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10250 Genomic island TA146566 879650..890975 0.002 View NZ_CP047546 Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10236 Genomic island TA146591 879605..890930 0.002 View NZ_CP047548 Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10169 Genomic island TA146631 4099471..4110051 0 View NZ_CP047555 Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10112 Genomic island TA146688 277854..288434 0 View NZ_CP060670 Salmonella enterica strain 190807_1 Genomic island TA170608 3086098..3096708 0.009 View NZ_CP060672 Salmonella enterica strain 190729_8 Genomic island TA170642 4030409..4041019 0.009 View NZ_CP060674 Salmonella enterica strain 190729_4 Genomic island TA170668 3416567..3427177 0.009 View NZ_CP060678 Salmonella enterica strain 190610_1 Genomic island TA170726 4028985..4039595 0.009 View NZ_CP064385 Salmonella enterica subsp. enterica strain PartC-Senterica-RM8376 Genomic island TA181072 1931625..1942917 0.002 View NZ_CP067091 Salmonella enterica subsp. enterica serovar Typhimurium strain ER3625 Genomic island TA185725 3124048..3135340 0.002 View NZ_CP067397 Salmonella enterica subsp. enterica serovar Typhimurium strain LB5000 Genomic island TA186254 3124780..3136072 0.002 View NZ_CP068018 Salmonella enterica strain 1722 Genomic island TA186450 3853717..3864297 0 View NZ_CP068696 Salmonella enterica subsp. enterica serovar Typhimurium strain NCCP16345 Genomic island TA187603 1319973..1331298 0.002 View NZ_CP074092 Salmonella enterica subsp. enterica serovar Typhimurium strain SO_8752_Stm Genomic island TA201377 3186004..3197296 0.002 View NZ_CP074663 Salmonella enterica subsp. enterica serovar Typhimurium strain CFSAN008081 Genomic island TA202568 848777..860102 0.002 View NZ_CP075141 Salmonella enterica strain CFSAN033950 Genomic island TA203274 841426..852751 0.002 View NZ_CP075372 Salmonella enterica strain no75 Genomic island TA203513 929744..941069 0.002 View NZ_CP077668 Salmonella enterica strain SP Genomic island TA207381 880832..892157 0.002 View NZ_CP081187 Salmonella enterica strain sg1722-1 Genomic island TA212649 879487..890812 0.002 View NZ_CP081189 Salmonella enterica strain sg1722-2 Genomic island TA212673 879687..891012 0.002 View NZ_CP085792 Salmonella enterica subsp. enterica serovar Enteritidis strain Mightyena Genomic island TA221305 767003..777613 0.009 View NZ_CP085793 Salmonella enterica subsp. enterica serovar Enteritidis strain Poochyena Genomic island TA221351 3723731..3734341 0.009 View NZ_CP085794 Salmonella enterica subsp. enterica serovar Enteritidis strain Greninja Genomic island TA221357 325976..336586 0.009 View NZ_CP085796 Salmonella enterica subsp. enterica serovar Enteritidis strain Froakie Genomic island TA221432 4305162..4315772 0.009 View NZ_CP085803 Salmonella enterica subsp. enterica serovar Enteritidis strain Glaceon Genomic island TA221611 3815985..3826595 0.009 View NZ_CP085804 Salmonella enterica subsp. enterica serovar Enteritidis strain Leafeon Genomic island TA221637 3721582..3732192 0.009 View NZ_CP085806 Salmonella enterica subsp. enterica serovar Enteritidis strain Marill Genomic island TA221687 3565071..3575681 0.009 View NZ_CP085814 Salmonella enterica subsp. enterica serovar Enteritidis strain Plusle Genomic island TA221851 4339565..4350175 0.009 View NZ_CP085817 Salmonella enterica subsp. enterica serovar Enteritidis strain Clefable Genomic island TA221928 4337378..4347988 0.009 View NZ_CP085819 Salmonella enterica subsp. enterica serovar Typhimurium strain Blastoise Genomic island TA221969 2743062..2754391 0.002 View NZ_CP085820 Salmonella enterica subsp. enterica serovar Typhimurium strain Wartortle Genomic island TA221981 843865..854445 0 View NZ_CP085821 Salmonella enterica subsp. enterica serovar Enteritidis strain Charizard Genomic island TA222022 3521808..3532418 0.009 View NZ_CP085823 Salmonella enterica subsp. enterica serovar Enteritidis strain Venusaur Genomic island TA222066 1909061..1919671 0.009 View NZ_CP085987 Salmonella enterica strain SZL 38 Genomic island TA222427 4325888..4336468 0 View NZ_CP086118 Salmonella enterica subsp. enterica serovar Typhimurium strain S34 Genomic island TA222550 879684..891009 0.002 View NZ_CP088138 Salmonella enterica subsp. enterica serovar Hissar strain SCPM-O-B-4549 Genomic island TA226792 879535..890860 0.002 View NZ_CP090304 Salmonella enterica subsp. enterica serovar Typhimurium strain ZJUJY Genomic island TA230386 3186004..3197296 0.002 View NZ_CP090529 Salmonella enterica strain 2008079-SE Genomic island TA231017 879493..890818 0.002 View NZ_CP090533 Salmonella enterica strain 2017005-SE Genomic island TA231059 3851334..3861914 0 View NZ_CP090535 Salmonella enterica strain 2016089-SE Genomic island TA231071 1038411..1048991 0 View NZ_CP090539 Salmonella enterica strain 2016062-SE Genomic island TA231097 960309..971634 0.002 View NZ_CP090541 Salmonella enterica strain 2010112-SE Genomic island TA231122 847708..859033 0.002 View NZ_CP090545 Salmonella enterica strain 2017028-SE Genomic island TA231147 960225..971550 0.002 View NZ_CP091540 Salmonella enterica subsp. enterica serovar Typhimurium strain S46L1 Genomic island TA233573 847454..858779 0.002 View NZ_CP091542 Salmonella enterica subsp. enterica serovar Typhimurium strain S58L2 Genomic island TA233600 847699..859024 0.002 View NZ_CP091544 Salmonella enterica strain 1618 Genomic island TA233627 962756..974081 0.002 View NZ_CP091547 Salmonella enterica strain 1559 Genomic island TA233665 3852931..3863511 0 View NZ_CP091554 Salmonella enterica strain 751 Genomic island TA233690 3774110..3784690 0 View NZ_CP091556 Salmonella enterica strain 632 Genomic island TA233702 882784..894109 0.002 View NZ_CP091558 Salmonella enterica strain 418 Genomic island TA233740 3720355..3731680 0.002 View NZ_CP091560 Salmonella enterica strain 179 Genomic island TA233752 877974..889299 0.002 View NZ_CP091563 Salmonella enterica strain 143 Genomic island TA233790 3854735..3865315 0 View NZ_CP091566 Salmonella enterica strain 137 Genomic island TA233805 269097..280422 0.002 View NZ_CP091569 Salmonella enterica strain 131 Genomic island TA233834 880756..892081 0.002 View NZ_CP091571 Salmonella enterica strain Genomic island TA233859 879684..890628 0.001 View NZ_CP093386 Salmonella enterica strain P048595 Genomic island TA238352 848654..859979 0.002 View NZ_CP094332 Salmonella enterica subsp. enterica strain 3018683606 Genomic island TA239672 847706..859031 0.002 View NZ_CP098438 Salmonella enterica subsp. enterica serovar Typhimurium strain ATOMSal-L6 Genomic island TA247620 889478..901515 0.004 View NZ_CP098741 Salmonella enterica subsp. enterica serovar Typhimurium strain HJL222 Genomic island TA247950 1399689..1410981 0.002 View NZ_CP098834 Salmonella enterica subsp. enterica serovar Typhimurium strain GD19PS1 Genomic island TA248150 880107..891432 0.002 View NZ_CP099705 Salmonella enterica subsp. enterica serovar Typhimurium strain 013+ Genomic island TA249292 878077..889402 0.002 View NZ_CP100666 Salmonella enterica subsp. enterica serovar Enteritidis strain R18.1630 Genomic island TA250933 3643987..3654597 0.009 View NZ_CP100691 Salmonella enterica subsp. enterica serovar Typhimurium strain R17.3867 Genomic island TA251037 927343..938668 0.002 View NZ_CP100707 Salmonella enterica subsp. enterica serovar Typhimurium strain R18.0409 Genomic island TA251132 879723..891048 0.002 View NZ_CP100715 Salmonella enterica subsp. enterica serovar Typhimurium strain R17.5474 Genomic island TA251177 847708..859033 0.002 View NZ_CP100724 Salmonella enterica subsp. enterica serovar Enteritidis strain R17.1476 Genomic island TA251218 895744..906354 0.009 View NZ_CP100732 Salmonella enterica subsp. enterica serovar Typhimurium strain R18.1932 Genomic island TA251261 847680..859005 0.002 View NZ_CP100739 Salmonella enterica subsp. enterica serovar Typhimurium strain R18.0292 Genomic island TA251305 847680..859005 0.002 View NZ_CP101373 Salmonella enterica strain SC2016042 Genomic island TA251970 928446..939771 0.002 View NZ_CP101375 Salmonella enterica strain SC2016090 Genomic island TA251994 1532769..1544094 0.002 View NZ_CP101376 Salmonella enterica strain SC2016091 Genomic island TA252011 879681..891006 0.002 View NZ_CP101379 Salmonella enterica strain SC2016290 Genomic island TA252034 879681..891006 0.002 View NZ_CP101382 Salmonella enterica strain SC2017030 Genomic island TA252057 928446..939771 0.002 View NZ_CP101386 Salmonella enterica strain SC2017100 Genomic island TA252077 960422..971747 0.002 View NZ_CP101388 Salmonella enterica strain SC2017167 Genomic island TA252097 880392..891717 0.002 View NZ_CP101390 Salmonella enterica strain SC2017297 Genomic island TA252117 960414..971739 0.002 View NZ_CP102669 Salmonella enterica subsp. enterica serovar Typhimurium strain ATCC 14028 Genomic island TA253911 842290..853615 0.002 View NZ_CP104366 Salmonella enterica subsp. enterica serovar Typhimurium strain PNUSAS028809 Genomic island TA257778 847361..858686 0.002 View NZ_CP104484 Salmonella enterica strain SalSpp_sample_07_No.3 Genomic island TA258077 879568..890893 0.002 View NZ_CP110198 Salmonella enterica subsp. enterica serovar Typhimurium strain 1104-75 Genomic island TA263393 879352..890677 0.002 View NZ_CP110201 Salmonella enterica subsp. enterica serovar Typhimurium strain 1104-65 Genomic island TA263414 879552..890877 0.002 View NZ_CP110657 Salmonella enterica subsp. enterica strain S2122 Genomic island TA264086 1225282..1235862 0 View NZ_CP113535 Salmonella enterica strain ZLQ Genomic island TA265901 960425..971750 0.002 View NZ_CP113536 Salmonella enterica strain ZCX Genomic island TA265920 881343..892668 0.002 View NZ_CP113538 Salmonella enterica strain XSK Genomic island TA265954 877461..888786 0.002 View NZ_CP113541 Salmonella enterica strain CHC Genomic island TA266010 877577..888902 0.002 View NZ_CP116042 Salmonella enterica subsp. enterica serovar 14[5]12:i:- strain BL708 Genomic island TA267680 879453..890778 0.002 View NZ_CP117033 Salmonella enterica strain PIW95_S14_0299 Genomic island TA269883 879368..890693 0.002 View NZ_CP117184 Salmonella enterica subsp. enterica strain 123 Genomic island TA270051 3853418..3863998 0 View NZ_CP117244 Salmonella enterica subsp. enterica serovar Typhimurium strain ATCC 14028 Genomic island TA270171 842290..853615 0.002 View NZ_CP117338 Salmonella enterica subsp. enterica serovar Typhimurium strain RM095 Genomic island TA270610 847688..859013 0.003 View NZ_CP117357 Salmonella enterica subsp. enterica serovar Typhimurium strain RM096 Genomic island TA270766 877581..888906 0.002 View NZ_CP117370 Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain RM054 Genomic island TA270871 879676..891001 0.002 View NZ_CP117398 Salmonella enterica subsp. enterica serovar Typhimurium strain RM015 Genomic island TA271141 848949..860986 0.004 View NZ_CP117400 Salmonella enterica subsp. enterica serovar Typhimurium strain RM014 Genomic island TA271161 848949..860986 0.004 View NZ_CP117404 Salmonella enterica subsp. enterica serovar Typhimurium strain RM085 Genomic island TA271194 849165..861202 0.004 View NZ_CP120322 Salmonella enterica subsp. enterica serovar Enteritidis strain PS_Ent_1_2022 Genomic island TA274657 3907882..3918492 0.009 View NZ_CP121262 Salmonella enterica subsp. enterica serovar Typhimurium strain 013 Genomic island TA276142 848171..859496 0.002 View NZ_CP121298 Salmonella enterica subsp. enterica strain KKP 3080 Genomic island TA276255 1194451..1204695 0.005 View NZ_CP126138 Salmonella enterica subsp. enterica serovar Kottbus strain DSK01 Genomic island TA282656 848170..859495 0.002 View NZ_CP126325 Salmonella enterica subsp. enterica strain HL21 Genomic island TA282768 879262..892507 0.008 View NZ_OU015323 Salmonella enterica subsp. enterica serovar Typhimurium strain AUSMDU00004549 isolate AUSMDU00004549 Genomic island TA294627 4133482..4144807 0.002 View NZ_OU015340 Salmonella enterica subsp. enterica serovar Typhimurium strain AUSMDU00027944 isolate AUSMDU00027944 Genomic island TA294648 4131305..4142630 0.002 View NZ_OU015342 Salmonella enterica subsp. enterica serovar Typhimurium strain AUSMDU00007171 isolate AUSMDU00007171 Genomic island TA294658 879552..890877 0.002 View NC_016856 Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S Genomic island TA026056 3205849..3216429 0 View UFRD01000002 Salmonella enterica subsp. enterica serovar Typhimurium strain NCTC12023 Genomic island TA297244 4451871..4463194 0.002	inside	Genomic island	-	-	3207430..3218010	10580

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-123)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14938.30 Da
• Isoelectric Point: 7.2155

>T25956 WP_000911336.1 NC_016810:c3216274-3215876 [Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Nucleotide

• Length: 399 bp

>T25956 NC_016810:c3216274-3215876 [Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344]
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTTTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCGGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAATTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8514.51 Da
• Isoelectric Point: 5.0210

>AT25956 WP_000557549.1 NC_016810:c3216501-3216274 [Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Nucleotide

• Length: 228 bp

>AT25956 NC_016810:c3216501-3216274 [Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGAGGATGTGAA
ACATGTCGAAATCATTGCGGTTGGCAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGTACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTTTGA

Structures

Toxin

• PDB: 6IFC
• PDB: 6IFM

Antitoxin

• PDB: 6IFM
• AlphaFold DB: A0A3V2Y5V5