251994

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1534278..1534903 Replicon chromosome
Accession NZ_CP101375
Organism Salmonella enterica strain SC2016090

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag NMU33_RS07580 Protein ID WP_000911336.1
Coordinates 1534505..1534903 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag NMU33_RS07575 Protein ID WP_000557549.1
Coordinates 1534278..1534505 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU33_RS07545 (1529323) 1529323..1530840 + 1518 WP_000003339.1 lysine--tRNA ligase -
NMU33_RS07550 (1530916) 1530916..1531461 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
NMU33_RS07555 (1531726) 1531726..1532484 + 759 WP_000244329.1 amidase activator ActS -
NMU33_RS07565 (1532769) 1532769..1533575 - 807 WP_010989071.1 DUF1460 domain-containing protein -
NMU33_RS07570 (1533850) 1533850..1534101 - 252 WP_001540858.1 hypothetical protein -
NMU33_RS07575 (1534278) 1534278..1534505 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
NMU33_RS07580 (1534505) 1534505..1534903 + 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
NMU33_RS07585 (1535709) 1535709..1536245 + 537 WP_001038506.1 STM3031 family outer membrane protein -
NMU33_RS07590 (1536292) 1536292..1536924 + 633 WP_000835265.1 YfdX family protein -
NMU33_RS07595 (1537643) 1537643..1538227 + 585 WP_001244638.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1532769..1544094 11325


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T251994 WP_000911336.1 NZ_CP101375:1534505-1534903 [Salmonella enterica]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT251994 WP_000557549.1 NZ_CP101375:1534278-1534505 [Salmonella enterica]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References