Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4334334..4334959 Replicon chromosome
Accession NZ_CP085987
Organism Salmonella enterica strain SZL 38

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag LKX03_RS21805 Protein ID WP_000911336.1
Coordinates 4334334..4334732 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag LKX03_RS21810 Protein ID WP_000557549.1
Coordinates 4334732..4334959 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LKX03_RS21790 (4331010) 4331010..4331594 - 585 WP_001244638.1 fimbrial protein -
LKX03_RS21795 (4332313) 4332313..4332945 - 633 WP_000835265.1 YfdX family protein -
LKX03_RS21800 (4332992) 4332992..4333528 - 537 WP_001038506.1 STM3031 family outer membrane protein -
LKX03_RS21805 (4334334) 4334334..4334732 - 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
LKX03_RS21810 (4334732) 4334732..4334959 - 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
LKX03_RS21815 (4335136) 4335136..4335387 + 252 WP_001540858.1 hypothetical protein -
LKX03_RS21820 (4335662) 4335662..4336468 + 807 WP_010989071.1 DUF1460 domain-containing protein -
LKX03_RS21830 (4336753) 4336753..4337511 - 759 WP_000244329.1 amidase activator ActS -
LKX03_RS21835 (4337776) 4337776..4338321 + 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
LKX03_RS21840 (4338397) 4338397..4339914 - 1518 WP_000003339.1 lysine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 4325888..4336468 10580


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T222427 WP_000911336.1 NZ_CP085987:c4334732-4334334 [Salmonella enterica]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T222427 NZ_CP117852:c993701-993285 [Salmonella enterica subsp. enterica serovar Mbandaka]
ATGAGTAAAACCTACATGCTGGATACCTGCATCTGTTCTTTCATTATGCGCGAACAGCCGGAAGCTGTGCTGAAACGCCT
TGAGCAGGCAGTGCTGCGCCGCCATCGTATTGTGGTGTCGGCGATTACCTACGCCGAAATGCGTTTTGGCTGTACGGGCA
AAAAGGCCTCGCCGCGCCATGCCCAACTGGTTGATGCATTCTGTAGTCGCCTGGATGCCGTGCTGGCCTGGGACCGGGCG
GCAGTGGATGCCACCACAGAGATCCGTGCCGTACTGGCCGCCGTCGGTACGCCGATTGGATCAAACGATGCGGCTATCGC
CGGCCATGCCATTGCGTCCGGGGCGATACTGGTCACTAATAACGTGAGGGAGTTTGAGCGGGTACCGGGTTTGCAGTACG
AAGATTGGGTAAAATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT222427 WP_000557549.1 NZ_CP085987:c4334959-4334732 [Salmonella enterica]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT222427 NZ_CP117852:c993928-993698 [Salmonella enterica subsp. enterica serovar Mbandaka]
ATGCGAACCGTATCTGTATTTAAAAATGGCAATAACCGCGCGATCCGCCTTCCACGCGATCTGGATTTTGACGGCGTCAA
CGAACTTGAAATCTTCCGCGAAGGCGACACGATTATACTGCGCCCCGCCCGCCCTTCCTGGGGATCATTCCGTCATGAGG
AAAAAGCCAGCCCAGACTTTCTGACGGAACGCGAAGACATCATCAGCGATGAGGGACGCTTTGAACTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References