Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3730021..3730646 Replicon chromosome
Accession NZ_CP085804
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Leafeon

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag LJF49_RS18225 Protein ID WP_000911336.1
Coordinates 3730021..3730419 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag LJF49_RS18230 Protein ID WP_000557549.1
Coordinates 3730419..3730646 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF49_RS18210 (3726698) 3726698..3727279 - 582 WP_001244651.1 fimbrial protein -
LJF49_RS18215 (3727998) 3727998..3728630 - 633 WP_000835265.1 YfdX family protein -
LJF49_RS18220 (3728677) 3728677..3729213 - 537 WP_001038502.1 STM3031 family outer membrane protein -
LJF49_RS18225 (3730021) 3730021..3730419 - 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
LJF49_RS18230 (3730419) 3730419..3730646 - 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
LJF49_RS18235 (3730855) 3730855..3731106 + 252 WP_001576352.1 hypothetical protein -
LJF49_RS18240 (3731386) 3731386..3732192 + 807 WP_001574939.1 DUF1460 domain-containing protein -
LJF49_RS18250 (3732477) 3732477..3733235 - 759 WP_000244328.1 amidase activator ActS -
LJF49_RS18255 (3733500) 3733500..3734045 + 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
LJF49_RS18260 (3734121) 3734121..3735638 - 1518 WP_000003339.1 lysine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3721582..3732192 10610


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T221637 WP_000911336.1 NZ_CP085804:c3730419-3730021 [Salmonella enterica subsp. enterica serovar Enteritidis]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T221637 NZ_CP117558:c576628-576164 [Escherichia albertii]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAACCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTTTCGTCTCTTCTTTCGTTACAGCGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACACTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCAAGAGACAGAAGAAAAGCATTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT221637 WP_000557549.1 NZ_CP085804:c3730646-3730419 [Salmonella enterica subsp. enterica serovar Enteritidis]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT221637 NZ_CP117558:c576963-576628 [Escherichia albertii]
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCTGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACAGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References