Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 881901..882526 Replicon chromosome
Accession NZ_CP101388
Organism Salmonella enterica strain SC2017167

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag NMU38_RS04300 Protein ID WP_000911336.1
Coordinates 882128..882526 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag NMU38_RS04295 Protein ID WP_000557549.1
Coordinates 881901..882128 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU38_RS04265 (876946) 876946..878463 + 1518 WP_000003339.1 lysine--tRNA ligase -
NMU38_RS04270 (878539) 878539..879084 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
NMU38_RS04275 (879349) 879349..880107 + 759 WP_000244329.1 amidase activator ActS -
NMU38_RS04285 (880392) 880392..881198 - 807 WP_010989071.1 DUF1460 domain-containing protein -
NMU38_RS04290 (881473) 881473..881724 - 252 WP_001540858.1 hypothetical protein -
NMU38_RS04295 (881901) 881901..882128 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
NMU38_RS04300 (882128) 882128..882526 + 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
NMU38_RS04305 (883332) 883332..883868 + 537 WP_001038506.1 STM3031 family outer membrane protein -
NMU38_RS04310 (883915) 883915..884547 + 633 WP_000835265.1 YfdX family protein -
NMU38_RS04315 (885266) 885266..885850 + 585 WP_001244638.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 880392..891717 11325


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T252097 WP_000911336.1 NZ_CP101388:882128-882526 [Salmonella enterica]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT252097 WP_000557549.1 NZ_CP101388:881901-882128 [Salmonella enterica]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References