267680

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 880962..881587 Replicon chromosome
Accession NZ_CP116042
Organism Salmonella enterica subsp. enterica serovar 14[5]12:i:- strain BL708

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag PGC28_RS04305 Protein ID WP_000911336.1
Coordinates 881189..881587 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag PGC28_RS04300 Protein ID WP_000557549.1
Coordinates 880962..881189 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PGC28_RS04270 (876007) 876007..877524 + 1518 WP_000003339.1 lysine--tRNA ligase -
PGC28_RS04275 (877600) 877600..878145 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
PGC28_RS04280 (878410) 878410..879168 + 759 WP_000244329.1 amidase activator ActS -
PGC28_RS04290 (879453) 879453..880259 - 807 WP_010989071.1 DUF1460 domain-containing protein -
PGC28_RS04295 (880534) 880534..880785 - 252 WP_001540858.1 hypothetical protein -
PGC28_RS04300 (880962) 880962..881189 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
PGC28_RS04305 (881189) 881189..881587 + 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
PGC28_RS04310 (882393) 882393..882929 + 537 WP_001038506.1 STM3031 family outer membrane protein -
PGC28_RS04315 (882976) 882976..883608 + 633 WP_000835265.1 YfdX family protein -
PGC28_RS04320 (884327) 884327..884911 + 585 WP_001244638.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 879453..890778 11325


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T267680 WP_000911336.1 NZ_CP116042:881189-881587 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T267680 NZ_CP116042:881189-881587 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTTTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCGGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAATTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT267680 WP_000557549.1 NZ_CP116042:880962-881189 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT267680 NZ_CP116042:880962-881189 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGAGGATGTGAA
ACATGTCGAAATCATTGCGGTTGGCAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGTACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References