294627

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4134991..4135616 Replicon chromosome
Accession NZ_OU015323
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain AUSMDU00004549 isolate AUSMDU00004549

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag KKQ99_RS20890 Protein ID WP_000911336.1
Coordinates 4135218..4135616 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag KKQ99_RS20885 Protein ID WP_000557549.1
Coordinates 4134991..4135218 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KKQ99_RS20855 (4130036) 4130036..4131553 + 1518 WP_000003339.1 lysine--tRNA ligase -
KKQ99_RS20860 (4131629) 4131629..4132174 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
KKQ99_RS20865 (4132439) 4132439..4133197 + 759 WP_000244329.1 amidase activator ActS -
KKQ99_RS20875 (4133482) 4133482..4134288 - 807 WP_010989071.1 DUF1460 domain-containing protein -
KKQ99_RS20880 (4134563) 4134563..4134814 - 252 WP_001540858.1 hypothetical protein -
KKQ99_RS20885 (4134991) 4134991..4135218 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
KKQ99_RS20890 (4135218) 4135218..4135616 + 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
KKQ99_RS20895 (4136422) 4136422..4136958 + 537 WP_001038506.1 STM3031 family outer membrane protein -
KKQ99_RS20900 (4137005) 4137005..4137637 + 633 WP_000835265.1 YfdX family protein -
KKQ99_RS20905 (4138356) 4138356..4138940 + 585 WP_001244638.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 4133482..4144807 11325


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T294627 WP_000911336.1 NZ_OU015323:4135218-4135616 [Salmonella enterica subsp. enterica serovar Typhimurium]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT294627 WP_000557549.1 NZ_OU015323:4134991-4135218 [Salmonella enterica subsp. enterica serovar Typhimurium]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References