146401

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4117278..4117903 Replicon chromosome
Accession NZ_CP047527
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10648

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag DXN11_RS20190 Protein ID WP_000911336.1
Coordinates 4117278..4117676 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag DXN11_RS20195 Protein ID WP_000557549.1
Coordinates 4117676..4117903 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN11_RS20175 (4113954) 4113954..4114538 - 585 WP_001244638.1 fimbrial protein -
DXN11_RS20180 (4115257) 4115257..4115889 - 633 WP_000835265.1 YfdX family protein -
DXN11_RS20185 (4115936) 4115936..4116472 - 537 WP_001038506.1 STM3031 family outer membrane protein -
DXN11_RS20190 (4117278) 4117278..4117676 - 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
DXN11_RS20195 (4117676) 4117676..4117903 - 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
DXN11_RS20200 (4118080) 4118080..4118331 + 252 WP_001540858.1 hypothetical protein -
DXN11_RS20205 (4118606) 4118606..4119412 + 807 WP_010989071.1 DUF1460 domain-containing protein -
DXN11_RS20215 (4119697) 4119697..4120455 - 759 WP_000244329.1 amidase activator ActS -
DXN11_RS20220 (4120720) 4120720..4121265 + 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
DXN11_RS20225 (4121341) 4121341..4122858 - 1518 WP_000003339.1 lysine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 4108832..4119412 10580


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T146401 WP_000911336.1 NZ_CP047527:c4117676-4117278 [Salmonella enterica subsp. enterica serovar Typhimurium]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T146401 NZ_CP062746:c2597857-2597750 [Escherichia coli O157:H7]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT146401 WP_000557549.1 NZ_CP047527:c4117903-4117676 [Salmonella enterica subsp. enterica serovar Typhimurium]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT146401 NZ_CP062746:2597910-2597971 [Escherichia coli O157:H7]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References