Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 849317..849942 Replicon chromosome
Accession NZ_AP023292
Organism Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4233

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag K5617_RS04105 Protein ID WP_000911336.1
Coordinates 849544..849942 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag K5617_RS04100 Protein ID WP_000557549.1
Coordinates 849317..849544 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5617_RS04070 (844362) 844362..845879 + 1518 WP_000003339.1 lysine--tRNA ligase -
K5617_RS04075 (845955) 845955..846500 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
K5617_RS04080 (846765) 846765..847523 + 759 WP_000244329.1 amidase activator ActS -
K5617_RS04090 (847808) 847808..848614 - 807 WP_010989071.1 DUF1460 domain-containing protein -
K5617_RS04095 (848889) 848889..849140 - 252 WP_001540858.1 hypothetical protein -
K5617_RS04100 (849317) 849317..849544 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
K5617_RS04105 (849544) 849544..849942 + 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
K5617_RS04110 (850748) 850748..851284 + 537 WP_001038506.1 STM3031 family outer membrane protein -
K5617_RS04115 (851331) 851331..851963 + 633 WP_000835265.1 YfdX family protein -
K5617_RS04120 (852682) 852682..853266 + 585 WP_001244638.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 847808..859133 11325


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T37269 WP_000911336.1 NZ_AP023292:849544-849942 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T37269 NZ_AP023292:849544-849942 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTTTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCGGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAATTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT37269 WP_000557549.1 NZ_AP023292:849317-849544 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT37269 NZ_AP023292:849317-849544 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGAGGATGTGAA
ACATGTCGAAATCATTGCGGTTGGCAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGTACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References