233834

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 882265..882890 Replicon chromosome
Accession NZ_CP091569
Organism Salmonella enterica strain 131

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag INN75_RS04300 Protein ID WP_000911336.1
Coordinates 882492..882890 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag INN75_RS04295 Protein ID WP_000557549.1
Coordinates 882265..882492 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INN75_RS04265 (877310) 877310..878827 + 1518 WP_000003339.1 lysine--tRNA ligase -
INN75_RS04270 (878903) 878903..879448 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
INN75_RS04275 (879713) 879713..880471 + 759 WP_000244329.1 amidase activator ActS -
INN75_RS04285 (880756) 880756..881562 - 807 WP_010989071.1 DUF1460 domain-containing protein -
INN75_RS04290 (881837) 881837..882088 - 252 WP_001540858.1 hypothetical protein -
INN75_RS04295 (882265) 882265..882492 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
INN75_RS04300 (882492) 882492..882890 + 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
INN75_RS04305 (883696) 883696..884232 + 537 WP_001038506.1 STM3031 family outer membrane protein -
INN75_RS04310 (884279) 884279..884911 + 633 WP_000835265.1 YfdX family protein -
INN75_RS04315 (885630) 885630..886214 + 585 WP_001244638.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 880756..892081 11325


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T233834 WP_000911336.1 NZ_CP091569:882492-882890 [Salmonella enterica]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T233834 NZ_LN831035:c1653963-1653715 [Haemophilus influenzae]
ATGGGACGAACTGAAAAATTATTAGATAAGCTCGCACAATCAAAATCTACATTTAATTGGAATGAATTAGTTTCTTTGTT
AGCTCAACAAGGTTATGAAAAGCGAGAAATGGCAGGCTCTCGAGTGAGATTTTATAATAGAACACTCGAACATACGATTT
TGTTACACAAGCCTCACCCTGAAAATTATATTAAAGGTGGTGCTTTAAAGTCAGTGAAAGAATCATTAAAACAGGTAGGT
ATTCTATGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT233834 WP_000557549.1 NZ_CP091569:882265-882492 [Salmonella enterica]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT233834 NZ_LN831035:c1653718-1653374 [Haemophilus influenzae]
ATGAAGTTATTAAATTATAAAGGTTATGTTGGCACGATTGAGGCGGATTTAGAAAACAATATATTGTTTGGCAAACTTGC
TTACATTCGTGATTTAGTGACTTACGAAGCAGAGTCATTATCTGAGCTAGAAAAAGAATTTCGTCAATCTGTTGATTTAT
ATTTACAAGATTGTTTGGAATTAGGTAAAGAACCGAATAAGCCTTTTAAAGGTGTATTTAATGTACGAATTGGCGAGGAA
TTGCATAGAGAAGCTACGATCATAGCAGGCGATCGTTCTCTTAATGCTTTTGTTACGGAAGCGATTCAAGAAAAAATTTT
TCGTGAAAAACCAAGTTTAAGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References