Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4038848..4039473 Replicon chromosome
Accession NZ_CP060672
Organism Salmonella enterica strain 190729_8

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag H9Q85_RS19620 Protein ID WP_000911336.1
Coordinates 4038848..4039246 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag H9Q85_RS19625 Protein ID WP_000557549.1
Coordinates 4039246..4039473 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9Q85_RS19605 (4035525) 4035525..4036106 - 582 WP_001244651.1 fimbrial protein -
H9Q85_RS19610 (4036825) 4036825..4037457 - 633 WP_000835265.1 YfdX family protein -
H9Q85_RS19615 (4037504) 4037504..4038040 - 537 WP_001038502.1 STM3031 family outer membrane protein -
H9Q85_RS19620 (4038848) 4038848..4039246 - 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
H9Q85_RS19625 (4039246) 4039246..4039473 - 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
H9Q85_RS19630 (4039682) 4039682..4039933 + 252 WP_001576352.1 hypothetical protein -
H9Q85_RS19635 (4040213) 4040213..4041019 + 807 WP_001574939.1 DUF1460 domain-containing protein -
H9Q85_RS19645 (4041304) 4041304..4042062 - 759 WP_000244328.1 amidase activator ActS -
H9Q85_RS19650 (4042327) 4042327..4042872 + 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
H9Q85_RS19655 (4042948) 4042948..4044465 - 1518 WP_000003339.1 lysine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 4030409..4041019 10610


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T170642 WP_000911336.1 NZ_CP060672:c4039246-4038848 [Salmonella enterica]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T170642 NZ_CP077663:792-1043 [Salmonella enterica]
ATGAGAAAAAATAAAGGTGATGTGACTTATTTTCTTGAAAAAGAAGGTGACAATTACAGGCTTACAAAAAGGATAAAAGC
CAGAACAAATGTTAAAATCGGGAACAAAACTACGAAAATTACATTGTATGATGCTGTACTGAATGAGAATGAATTACAAC
ATATTGATTTTACGTGTGCCGGATTAAGGGAAGACGATGAGACGCCAGTTAAGAATTTAATTAAGGAGTTTATGTTAAAT
GAAACCCGATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT170642 WP_000557549.1 NZ_CP060672:c4039473-4039246 [Salmonella enterica]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT170642 NZ_CP077663:1030-1257 [Salmonella enterica]
ATGAAACCCGATAATACACCTGAAAATGTAAAAAAATTACGTTTAAAAGCAGGATTAACACAAAAGGAATGCAGTCATAT
TTATGGTGTTGGGCTAAGAACCTGGCAGAAAAAAGAGGAAGTTAATACTCAAAACAGTCAAAGTCTGTCACTGGTTGAGT
TTGAGTTTCTTTTGTTACTTGCAGGAGAACATCCTGAATACGTGCTCTGCAAAAGGGAGTCAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References