Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 286300..286925 Replicon chromosome
Accession NZ_CP047555
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10112

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag DXN18_RS01380 Protein ID WP_000911336.1
Coordinates 286300..286698 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag DXN18_RS01385 Protein ID WP_000557549.1
Coordinates 286698..286925 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN18_RS01365 (282976) 282976..283560 - 585 WP_001244638.1 fimbrial protein -
DXN18_RS01370 (284279) 284279..284911 - 633 WP_000835265.1 YfdX family protein -
DXN18_RS01375 (284958) 284958..285494 - 537 WP_001038506.1 STM3031 family outer membrane protein -
DXN18_RS01380 (286300) 286300..286698 - 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
DXN18_RS01385 (286698) 286698..286925 - 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
DXN18_RS01390 (287102) 287102..287353 + 252 WP_001540858.1 hypothetical protein -
DXN18_RS01395 (287628) 287628..288434 + 807 WP_010989071.1 DUF1460 domain-containing protein -
DXN18_RS01405 (288719) 288719..289477 - 759 WP_000244329.1 amidase activator ActS -
DXN18_RS01410 (289742) 289742..290287 + 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
DXN18_RS01415 (290363) 290363..291880 - 1518 WP_000003339.1 lysine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 277854..288434 10580


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T146688 WP_000911336.1 NZ_CP047555:c286698-286300 [Salmonella enterica subsp. enterica serovar Typhimurium]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T146688 NZ_CP062774:365365-365640 [Escherichia coli O157:H7]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGC
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT146688 WP_000557549.1 NZ_CP047555:c286925-286698 [Salmonella enterica subsp. enterica serovar Typhimurium]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT146688 NZ_CP062774:365637-365996 [Escherichia coli O157:H7]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCTGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References