186450

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3862163..3862788 Replicon chromosome
Accession NZ_CP068018
Organism Salmonella enterica strain 1722

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag JI996_RS19110 Protein ID WP_000911336.1
Coordinates 3862163..3862561 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag JI996_RS19115 Protein ID WP_000557549.1
Coordinates 3862561..3862788 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JI996_RS19095 (3858839) 3858839..3859423 - 585 WP_001244638.1 fimbrial protein -
JI996_RS19100 (3860142) 3860142..3860774 - 633 WP_000835265.1 YfdX family protein -
JI996_RS19105 (3860821) 3860821..3861357 - 537 WP_001038506.1 STM3031 family outer membrane protein -
JI996_RS19110 (3862163) 3862163..3862561 - 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
JI996_RS19115 (3862561) 3862561..3862788 - 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
JI996_RS19120 (3862965) 3862965..3863216 + 252 WP_001540858.1 hypothetical protein -
JI996_RS19125 (3863491) 3863491..3864297 + 807 WP_010989071.1 DUF1460 domain-containing protein -
JI996_RS19135 (3864582) 3864582..3865340 - 759 WP_000244329.1 amidase activator ActS -
JI996_RS19140 (3865605) 3865605..3866150 + 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
JI996_RS19145 (3866226) 3866226..3867743 - 1518 WP_000003339.1 lysine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3853717..3864297 10580


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T186450 WP_000911336.1 NZ_CP068018:c3862561-3862163 [Salmonella enterica]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T186450 NZ_CP089445:c334147-333770 [Escherichia coli]
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCAACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACAATGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT186450 WP_000557549.1 NZ_CP068018:c3862788-3862561 [Salmonella enterica]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT186450 NZ_CP089445:c334571-334194 [Escherichia coli]
GTGTCAGACACACTGCCCGGGACAACGCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCATCACACTGTATGCGAAAGGGCTGACCTGCGAAGCCGATACCCTTGGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCAGCGCCCGCAATCACCGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References