251132

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 881232..881857 Replicon chromosome
Accession NZ_CP100707
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain R18.0409

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag NL735_RS04295 Protein ID WP_000911336.1
Coordinates 881459..881857 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag NL735_RS04290 Protein ID WP_000557549.1
Coordinates 881232..881459 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL735_RS04260 (876277) 876277..877794 + 1518 WP_000003339.1 lysine--tRNA ligase -
NL735_RS04265 (877870) 877870..878415 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
NL735_RS04270 (878680) 878680..879438 + 759 WP_000244329.1 amidase activator ActS -
NL735_RS04280 (879723) 879723..880529 - 807 WP_010989071.1 DUF1460 domain-containing protein -
NL735_RS04285 (880804) 880804..881055 - 252 WP_001540858.1 hypothetical protein -
NL735_RS04290 (881232) 881232..881459 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
NL735_RS04295 (881459) 881459..881857 + 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
NL735_RS04300 (882663) 882663..883199 + 537 WP_001038506.1 STM3031 family outer membrane protein -
NL735_RS04305 (883246) 883246..883878 + 633 WP_000835265.1 YfdX family protein -
NL735_RS04310 (884597) 884597..885181 + 585 WP_001244638.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 879723..891048 11325


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T251132 WP_000911336.1 NZ_CP100707:881459-881857 [Salmonella enterica subsp. enterica serovar Typhimurium]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT251132 WP_000557549.1 NZ_CP100707:881232-881459 [Salmonella enterica subsp. enterica serovar Typhimurium]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
AlphaFold DB A0A3V2Y5V5

References