247950

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1408847..1409472 Replicon chromosome
Accession NZ_CP098741
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain HJL222

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag NCG87_RS06870 Protein ID WP_000911336.1
Coordinates 1408847..1409245 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag NCG87_RS06875 Protein ID WP_000557549.1
Coordinates 1409245..1409472 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NCG87_RS06850 (1404811) 1404811..1405395 - 585 WP_001244638.1 fimbrial protein -
NCG87_RS06855 (1406114) 1406114..1406746 - 633 WP_000835265.1 YfdX family protein -
NCG87_RS06860 (1406793) 1406793..1407329 - 537 WP_001038506.1 STM3031 family outer membrane protein -
NCG87_RS06865 (1408009) 1408009..1408467 - 459 WP_000502119.1 IS200/IS605-like element IS200F family transposase -
NCG87_RS06870 (1408847) 1408847..1409245 - 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
NCG87_RS06875 (1409245) 1409245..1409472 - 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
NCG87_RS06880 (1409649) 1409649..1409900 + 252 WP_001540858.1 hypothetical protein -
NCG87_RS06885 (1410175) 1410175..1410981 + 807 WP_010989071.1 DUF1460 domain-containing protein -
NCG87_RS06895 (1411266) 1411266..1412024 - 759 WP_000244329.1 amidase activator ActS -
NCG87_RS06900 (1412289) 1412289..1412834 + 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
NCG87_RS06905 (1412910) 1412910..1414427 - 1518 WP_000003339.1 lysine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1399689..1410981 11292
flank IS/Tn - - 1408009..1408467 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T247950 WP_000911336.1 NZ_CP098741:c1409245-1408847 [Salmonella enterica subsp. enterica serovar Typhimurium]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT247950 WP_000557549.1 NZ_CP098741:c1409472-1409245 [Salmonella enterica subsp. enterica serovar Typhimurium]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References