Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 848870..849495 Replicon chromosome
Accession NZ_CP104366
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain PNUSAS028809

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag N4533_RS04100 Protein ID WP_000911336.1
Coordinates 849097..849495 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag N4533_RS04095 Protein ID WP_000557549.1
Coordinates 848870..849097 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4533_RS04065 (843915) 843915..845432 + 1518 WP_000003339.1 lysine--tRNA ligase -
N4533_RS04070 (845508) 845508..846053 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
N4533_RS04075 (846318) 846318..847076 + 759 WP_000244329.1 amidase activator ActS -
N4533_RS04085 (847361) 847361..848167 - 807 WP_010989071.1 DUF1460 domain-containing protein -
N4533_RS04090 (848442) 848442..848693 - 252 WP_001540858.1 hypothetical protein -
N4533_RS04095 (848870) 848870..849097 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
N4533_RS04100 (849097) 849097..849495 + 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
N4533_RS04105 (850301) 850301..850837 + 537 WP_001038506.1 STM3031 family outer membrane protein -
N4533_RS04110 (850884) 850884..851516 + 633 WP_000835265.1 YfdX family protein -
N4533_RS04115 (852235) 852235..852819 + 585 WP_001244638.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 847361..858686 11325


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T257778 WP_000911336.1 NZ_CP104366:849097-849495 [Salmonella enterica subsp. enterica serovar Typhimurium]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT257778 WP_000557549.1 NZ_CP104366:848870-849097 [Salmonella enterica subsp. enterica serovar Typhimurium]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References