274657

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3916321..3916946 Replicon chromosome
Accession NZ_CP120322
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain PS_Ent_1_2022

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag P1705_RS19220 Protein ID WP_000911336.1
Coordinates 3916321..3916719 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag P1705_RS19225 Protein ID WP_000557549.1
Coordinates 3916719..3916946 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1705_RS19205 (3912998) 3912998..3913579 - 582 WP_001244651.1 fimbrial protein -
P1705_RS19210 (3914298) 3914298..3914930 - 633 WP_000835265.1 YfdX family protein -
P1705_RS19215 (3914977) 3914977..3915513 - 537 WP_001038502.1 STM3031 family outer membrane protein -
P1705_RS19220 (3916321) 3916321..3916719 - 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
P1705_RS19225 (3916719) 3916719..3916946 - 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
P1705_RS19230 (3917155) 3917155..3917406 + 252 WP_001576352.1 hypothetical protein -
P1705_RS19235 (3917686) 3917686..3918492 + 807 WP_001574939.1 DUF1460 domain-containing protein -
P1705_RS19245 (3918777) 3918777..3919535 - 759 WP_000244328.1 amidase activator ActS -
P1705_RS19250 (3919800) 3919800..3920345 + 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
P1705_RS19255 (3920421) 3920421..3921939 - 1519 Protein_3725 lysine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3907882..3918492 10610


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T274657 WP_000911336.1 NZ_CP120322:c3916719-3916321 [Salmonella enterica subsp. enterica serovar Enteritidis]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT274657 WP_000557549.1 NZ_CP120322:c3916946-3916719 [Salmonella enterica subsp. enterica serovar Enteritidis]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
AlphaFold DB A0A3V2Y5V5

References