Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 881616..882241 Replicon chromosome
Accession NZ_CP098834
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain GD19PS1

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag NFH28_RS04290 Protein ID WP_000911336.1
Coordinates 881843..882241 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag NFH28_RS04285 Protein ID WP_000557549.1
Coordinates 881616..881843 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFH28_RS04255 (876661) 876661..878178 + 1518 WP_000003339.1 lysine--tRNA ligase -
NFH28_RS04260 (878254) 878254..878799 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
NFH28_RS04265 (879064) 879064..879822 + 759 WP_000244329.1 amidase activator ActS -
NFH28_RS04275 (880107) 880107..880913 - 807 WP_010989071.1 DUF1460 domain-containing protein -
NFH28_RS04280 (881188) 881188..881439 - 252 WP_001540858.1 hypothetical protein -
NFH28_RS04285 (881616) 881616..881843 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
NFH28_RS04290 (881843) 881843..882241 + 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
NFH28_RS04295 (883047) 883047..883583 + 537 WP_001038506.1 STM3031 family outer membrane protein -
NFH28_RS04300 (883630) 883630..884262 + 633 WP_000835265.1 YfdX family protein -
NFH28_RS04305 (884981) 884981..885565 + 585 WP_001244638.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 880107..891432 11325


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T248150 WP_000911336.1 NZ_CP098834:881843-882241 [Salmonella enterica subsp. enterica serovar Typhimurium]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT248150 WP_000557549.1 NZ_CP098834:881616-881843 [Salmonella enterica subsp. enterica serovar Typhimurium]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References