Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3861377..3862002 Replicon chromosome
Accession NZ_CP091547
Organism Salmonella enterica strain 1559

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag L4413_RS19095 Protein ID WP_000911336.1
Coordinates 3861377..3861775 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag L4413_RS19100 Protein ID WP_000557549.1
Coordinates 3861775..3862002 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L4413_RS19080 (3858053) 3858053..3858637 - 585 WP_001244638.1 fimbrial protein -
L4413_RS19085 (3859356) 3859356..3859988 - 633 WP_000835265.1 YfdX family protein -
L4413_RS19090 (3860035) 3860035..3860571 - 537 WP_001038506.1 STM3031 family outer membrane protein -
L4413_RS19095 (3861377) 3861377..3861775 - 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
L4413_RS19100 (3861775) 3861775..3862002 - 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
L4413_RS19105 (3862179) 3862179..3862430 + 252 WP_001540858.1 hypothetical protein -
L4413_RS19110 (3862705) 3862705..3863511 + 807 WP_010989071.1 DUF1460 domain-containing protein -
L4413_RS19120 (3863796) 3863796..3864554 - 759 WP_000244329.1 amidase activator ActS -
L4413_RS19125 (3864819) 3864819..3865364 + 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
L4413_RS19130 (3865440) 3865440..3866957 - 1518 WP_000003339.1 lysine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3852931..3863511 10580


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T233665 WP_000911336.1 NZ_CP091547:c3861775-3861377 [Salmonella enterica]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T233665 NZ_LM993812:c479531-479313 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT233665 WP_000557549.1 NZ_CP091547:c3862002-3861775 [Salmonella enterica]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT233665 NZ_LM993812:c479931-479557 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References