271141

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 850458..851083 Replicon chromosome
Accession NZ_CP117398
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain RM015

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag PQQ09_RS04115 Protein ID WP_000911336.1
Coordinates 850685..851083 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag PQQ09_RS04110 Protein ID WP_000557549.1
Coordinates 850458..850685 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ09_RS04080 (845503) 845503..847020 + 1518 WP_000003339.1 lysine--tRNA ligase -
PQQ09_RS04085 (847096) 847096..847641 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
PQQ09_RS04090 (847906) 847906..848664 + 759 WP_000244329.1 amidase activator ActS -
PQQ09_RS04100 (848949) 848949..849755 - 807 WP_010989071.1 DUF1460 domain-containing protein -
PQQ09_RS04105 (850030) 850030..850281 - 252 WP_001540858.1 hypothetical protein -
PQQ09_RS04110 (850458) 850458..850685 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
PQQ09_RS04115 (850685) 850685..851083 + 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
PQQ09_RS04120 (851463) 851463..851921 + 459 WP_000502119.1 IS200/IS605-like element IS200F family transposase -
PQQ09_RS04125 (852601) 852601..853137 + 537 WP_001038506.1 STM3031 family outer membrane protein -
PQQ09_RS04130 (853184) 853184..853816 + 633 WP_000835265.1 YfdX family protein -
PQQ09_RS04135 (854535) 854535..855119 + 585 WP_001244638.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 848949..860986 12037
flank IS/Tn - - 851463..851921 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T271141 WP_000911336.1 NZ_CP117398:850685-851083 [Salmonella enterica subsp. enterica serovar Typhimurium]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT271141 WP_000557549.1 NZ_CP117398:850458-850685 [Salmonella enterica subsp. enterica serovar Typhimurium]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References