Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 278288..278913 Replicon chromosome
Accession NZ_CP091566
Organism Salmonella enterica strain 137

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag INN76_RS01330 Protein ID WP_000911336.1
Coordinates 278288..278686 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag INN76_RS01335 Protein ID WP_000557549.1
Coordinates 278686..278913 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INN76_RS01315 (274964) 274964..275548 - 585 WP_001244638.1 fimbrial protein -
INN76_RS01320 (276267) 276267..276899 - 633 WP_000835265.1 YfdX family protein -
INN76_RS01325 (276946) 276946..277482 - 537 WP_001038506.1 STM3031 family outer membrane protein -
INN76_RS01330 (278288) 278288..278686 - 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
INN76_RS01335 (278686) 278686..278913 - 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
INN76_RS01340 (279090) 279090..279341 + 252 WP_001540858.1 hypothetical protein -
INN76_RS01345 (279616) 279616..280422 + 807 WP_010989071.1 DUF1460 domain-containing protein -
INN76_RS01355 (280707) 280707..281465 - 759 WP_000244329.1 amidase activator ActS -
INN76_RS01360 (281730) 281730..282275 + 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
INN76_RS01365 (282351) 282351..283868 - 1518 WP_000003339.1 lysine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 269097..280422 11325


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T233805 WP_000911336.1 NZ_CP091566:c278686-278288 [Salmonella enterica]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T233805 NZ_LN824138:c63460-63302 [Klebsiella pneumoniae]
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT233805 WP_000557549.1 NZ_CP091566:c278913-278686 [Salmonella enterica]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT233805 NZ_LN824138:c63728-63504 [Klebsiella pneumoniae]
TCACACAGATTACCCGTAAACAGCCTGAATGAGCGGGTTATTTTCAGGAAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References