Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 881002..881627 Replicon chromosome
Accession NZ_CP090529
Organism Salmonella enterica strain 2008079-SE

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag L0F60_RS04285 Protein ID WP_000911336.1
Coordinates 881229..881627 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag L0F60_RS04280 Protein ID WP_000557549.1
Coordinates 881002..881229 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0F60_RS04250 (876047) 876047..877564 + 1518 WP_000003339.1 lysine--tRNA ligase -
L0F60_RS04255 (877640) 877640..878185 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
L0F60_RS04260 (878450) 878450..879208 + 759 WP_000244329.1 amidase activator ActS -
L0F60_RS04270 (879493) 879493..880299 - 807 WP_010989071.1 DUF1460 domain-containing protein -
L0F60_RS04275 (880574) 880574..880825 - 252 WP_001540858.1 hypothetical protein -
L0F60_RS04280 (881002) 881002..881229 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
L0F60_RS04285 (881229) 881229..881627 + 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
L0F60_RS04290 (882433) 882433..882969 + 537 WP_001038506.1 STM3031 family outer membrane protein -
L0F60_RS04295 (883016) 883016..883648 + 633 WP_000835265.1 YfdX family protein -
L0F60_RS04300 (884367) 884367..884951 + 585 WP_001244638.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 879493..890818 11325


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T231017 WP_000911336.1 NZ_CP090529:881229-881627 [Salmonella enterica]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T231017 NZ_CP125879:c337116-336691 [Auritidibacter ignavus]
GTGATCATCCTCGACACAAACGTGATCTCGGAGATCTTTCGACCCTTGCCCGAGCCACGCGTAGCGGACTGGCTCACGTC
CCTGGAGGGTGACGTAGCCATCACGTCCGTCACGCTCGCAGAACTGCTGGCAGGTTTGCGGCGGTTGCCGGATGGTCGGC
GCAGAGATGCGCTGACCAGACGAATTGACGTGGCGCTCGCACCGTACAGGGGCGGCCGCGCTGTGTTGCCGTTCGATGAC
GTGGCCGCCGACCGCTATGCCGACGTGCTCGTGGCTCGAGAGCGCGCGGGAGCGCCGATCAGTACCGCCGACGCGCAGAT
CGCCGCGATCTGCCTGGCGCACGGAGCAACCTGCGCTACGCGCAATGTGAAGGACTTCCAGCACACCGGCGTAGAACTGG
TGGATCCGTGGAAGGTCGATGCGTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT231017 WP_000557549.1 NZ_CP090529:881002-881229 [Salmonella enterica]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT231017 NZ_CP125879:c337346-337113 [Auritidibacter ignavus]
ATGTCATCCATCATCGTTCGCGGTCTCGACGACGCCGTGAAGCAGCAACTCGCTGCACAGGCGAAGGAGCACGGTCGGTC
GATGGAAGCCGAAGTTCGCGCCATCCTGACCAAAGCTGCACGCCGGCCGCACATAGGAATCGCTCTGCTGGCAGCCGCGC
AGGATGTCGGGGGAGTCGAGGAGCTACCGATCCCGGTGCGCGATGACGTCGCGCGGGCGGTGGACTTCGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References