212673

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 881196..881821 Replicon chromosome
Accession NZ_CP081189
Organism Salmonella enterica strain sg1722-2

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag K4F90_RS04290 Protein ID WP_000911336.1
Coordinates 881423..881821 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag K4F90_RS04285 Protein ID WP_000557549.1
Coordinates 881196..881423 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K4F90_RS04255 (876241) 876241..877758 + 1518 WP_000003339.1 lysine--tRNA ligase -
K4F90_RS04260 (877834) 877834..878379 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
K4F90_RS04265 (878644) 878644..879402 + 759 WP_000244329.1 amidase activator ActS -
K4F90_RS04275 (879687) 879687..880493 - 807 WP_010989071.1 DUF1460 domain-containing protein -
K4F90_RS04280 (880768) 880768..881019 - 252 WP_001540858.1 hypothetical protein -
K4F90_RS04285 (881196) 881196..881423 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
K4F90_RS04290 (881423) 881423..881821 + 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
K4F90_RS04295 (882627) 882627..883163 + 537 WP_001038506.1 STM3031 family outer membrane protein -
K4F90_RS04300 (883210) 883210..883842 + 633 WP_000835265.1 YfdX family protein -
K4F90_RS04305 (884561) 884561..885145 + 585 WP_001244638.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 879687..891012 11325


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T212673 WP_000911336.1 NZ_CP081189:881423-881821 [Salmonella enterica]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T212673 NZ_CP107319:4032-4298 [Klebsiella pneumoniae]
TTGGTCTGGACGATTAACTATTCCGATCGGGCGCTCAAATCGTTACGCAAGATGGACAAACAGAACGCACGACGGATTGT
GGATTTTATGAGTTTACGCATTGCAGTTGCTGCCGATCCTCGCCAGTCAGGGAAGCCGCTCAAAGGTGAGCTGGGCGAGT
TCTGGCGCTATCGGGTGGGAGATTATCGCGTTCTGTGTGAGATCCGAGATGACGAGCTTGTTATCCTTGCCGCCACGATT
GGACATCGCCGCGAAGTTTACGACTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT212673 WP_000557549.1 NZ_CP081189:881196-881423 [Salmonella enterica]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT212673 NZ_CP107319:3824-4048 [Klebsiella pneumoniae]
ATGCTTGCTATCCGGTTATCTGATGAGATTGAGTCCCGTCTGGACTCGCTGGCGAAGCAAACCGGCAGAACAAAGACGTT
TTATGCGCGGGAAGCAATACTGGCGCATCTGGAAGACCTGGAGGATTATTATCTTTCAGCAGAAACTGCTGCACGCGTTC
GCCGTGGTGATGAAGCAGTGCATTCGTCTGAAGACGTGAGGAAGTCACTTGGTCTGGACGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References