221351

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3732170..3732795 Replicon chromosome
Accession NZ_CP085793
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Poochyena

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag LJF61_RS18205 Protein ID WP_000911336.1
Coordinates 3732170..3732568 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag LJF61_RS18210 Protein ID WP_000557549.1
Coordinates 3732568..3732795 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF61_RS18190 (3728847) 3728847..3729428 - 582 WP_001244651.1 fimbrial protein -
LJF61_RS18195 (3730147) 3730147..3730779 - 633 WP_000835265.1 YfdX family protein -
LJF61_RS18200 (3730826) 3730826..3731362 - 537 WP_001038502.1 STM3031 family outer membrane protein -
LJF61_RS18205 (3732170) 3732170..3732568 - 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
LJF61_RS18210 (3732568) 3732568..3732795 - 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
LJF61_RS18215 (3733004) 3733004..3733255 + 252 WP_001576352.1 hypothetical protein -
LJF61_RS18220 (3733535) 3733535..3734341 + 807 WP_001574939.1 DUF1460 domain-containing protein -
LJF61_RS18230 (3734626) 3734626..3735384 - 759 WP_000244328.1 amidase activator ActS -
LJF61_RS18235 (3735649) 3735649..3736194 + 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
LJF61_RS18240 (3736270) 3736270..3737787 - 1518 WP_000003339.1 lysine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3723731..3734341 10610


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T221351 WP_000911336.1 NZ_CP085793:c3732568-3732170 [Salmonella enterica subsp. enterica serovar Enteritidis]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T221351 NZ_CP117382:839477-839890 [Salmonella enterica subsp. enterica serovar Uganda]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTTCTGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT221351 WP_000557549.1 NZ_CP085793:c3732795-3732568 [Salmonella enterica subsp. enterica serovar Enteritidis]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT221351 NZ_CP117382:839230-839496 [Salmonella enterica subsp. enterica serovar Uganda]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
AlphaFold DB A0A3V2Y5V5

References