Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 775442..776067 Replicon chromosome
Accession NZ_CP085792
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Mightyena

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag LJF62_RS03625 Protein ID WP_000911336.1
Coordinates 775442..775840 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag LJF62_RS03630 Protein ID WP_000557549.1
Coordinates 775840..776067 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF62_RS03610 (772119) 772119..772700 - 582 WP_001244651.1 fimbrial protein -
LJF62_RS03615 (773419) 773419..774051 - 633 WP_000835265.1 YfdX family protein -
LJF62_RS03620 (774098) 774098..774634 - 537 WP_001038502.1 STM3031 family outer membrane protein -
LJF62_RS03625 (775442) 775442..775840 - 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
LJF62_RS03630 (775840) 775840..776067 - 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
LJF62_RS03635 (776276) 776276..776527 + 252 WP_001576352.1 hypothetical protein -
LJF62_RS03640 (776807) 776807..777613 + 807 WP_001574939.1 DUF1460 domain-containing protein -
LJF62_RS03650 (777898) 777898..778656 - 759 WP_000244328.1 amidase activator ActS -
LJF62_RS03655 (778921) 778921..779466 + 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
LJF62_RS03660 (779542) 779542..781059 - 1518 WP_000003339.1 lysine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 767003..777613 10610


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T221305 WP_000911336.1 NZ_CP085792:c775840-775442 [Salmonella enterica subsp. enterica serovar Enteritidis]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T221305 NZ_CP117373:3741211-3741468 [Salmonella enterica subsp. enterica serovar Dublin]
ATGAATGCCTCCGGCGTCAGCGTCCGCCACATCAACAGCAAAACCCACATGACCACCTATTACTCACAAATCCCCAGCCT
GCATCTTAAGGGCGACTGGCTGGAAGAAGCGGGATTTAAGACCGGGCGCGGCGTCACCGTGAAGATTTCACAGGGGTGTA
TTGTGCTGATGGCGGACAGTAACGAGGAGCAGAAGCTGCGCGAGCAGCTTTATCAGGCTAAACAGGTGGTTAAGGGAATT
AAGGACGTGCTGGTTTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT221305 WP_000557549.1 NZ_CP085792:c776067-775840 [Salmonella enterica subsp. enterica serovar Enteritidis]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT221305 NZ_CP117373:c3741386-3741054 [Salmonella enterica subsp. enterica serovar Dublin]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References