181072

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1940783..1941408 Replicon chromosome
Accession NZ_CP064385
Organism Salmonella enterica subsp. enterica strain PartC-Senterica-RM8376

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag IUJ38_RS09585 Protein ID WP_000911336.1
Coordinates 1940783..1941181 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag IUJ38_RS09590 Protein ID WP_000557549.1
Coordinates 1941181..1941408 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUJ38_RS09565 (1936747) 1936747..1937331 - 585 WP_001244638.1 fimbrial protein -
IUJ38_RS09570 (1938050) 1938050..1938682 - 633 WP_000835265.1 YfdX family protein -
IUJ38_RS09575 (1938729) 1938729..1939265 - 537 WP_001038506.1 STM3031 family outer membrane protein -
IUJ38_RS09580 (1939945) 1939945..1940403 - 459 WP_000502119.1 IS200/IS605-like element IS200F family transposase -
IUJ38_RS09585 (1940783) 1940783..1941181 - 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
IUJ38_RS09590 (1941181) 1941181..1941408 - 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
IUJ38_RS09595 (1941585) 1941585..1941836 + 252 WP_001540858.1 hypothetical protein -
IUJ38_RS09600 (1942111) 1942111..1942917 + 807 WP_010989071.1 DUF1460 domain-containing protein -
IUJ38_RS09610 (1943202) 1943202..1943960 - 759 WP_000244329.1 amidase activator ActS -
IUJ38_RS09615 (1944225) 1944225..1944770 + 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
IUJ38_RS09620 (1944846) 1944846..1946363 - 1518 WP_000003339.1 lysine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1931625..1942917 11292
flank IS/Tn - - 1939945..1940403 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T181072 WP_000911336.1 NZ_CP064385:c1941181-1940783 [Salmonella enterica subsp. enterica]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T181072 NZ_CP085802:c2011900-2011745 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT181072 WP_000557549.1 NZ_CP064385:c1941408-1941181 [Salmonella enterica subsp. enterica]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT181072 NZ_CP085802:2011912-2011970 [Salmonella enterica subsp. enterica serovar Enteritidis]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
AlphaFold DB A0A3V2Y5V5

References