Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 849680..850305 Replicon chromosome
Accession NZ_CP121262
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain 013

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag P8621_RS04115 Protein ID WP_080247813.1
Coordinates 849907..850305 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag P8621_RS04110 Protein ID WP_000557549.1
Coordinates 849680..849907 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8621_RS04080 (844725) 844725..846242 + 1518 WP_000003339.1 lysine--tRNA ligase -
P8621_RS04085 (846318) 846318..846863 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
P8621_RS04090 (847128) 847128..847886 + 759 WP_000244329.1 amidase activator ActS -
P8621_RS04100 (848171) 848171..848977 - 807 WP_010989071.1 DUF1460 domain-containing protein -
P8621_RS04105 (849252) 849252..849503 - 252 WP_001540858.1 hypothetical protein -
P8621_RS04110 (849680) 849680..849907 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
P8621_RS04115 (849907) 849907..850305 + 399 WP_080247813.1 tRNA(fMet)-specific endonuclease VapC Toxin
P8621_RS04120 (851111) 851111..851647 + 537 WP_001038506.1 STM3031 family outer membrane protein -
P8621_RS04125 (851694) 851694..852326 + 633 WP_000835265.1 YfdX family protein -
P8621_RS04130 (853045) 853045..853629 + 585 WP_001244638.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 848171..859496 11325


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14926.24 Da        Isoelectric Point: 7.2155

>T276142 WP_080247813.1 NZ_CP121262:849907-850305 [Salmonella enterica subsp. enterica serovar Typhimurium]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRTEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT276142 WP_000557549.1 NZ_CP121262:849680-849907 [Salmonella enterica subsp. enterica serovar Typhimurium]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References