146556

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4117191..4117816 Replicon chromosome
Accession NZ_CP047542
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10330

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag DXN30_RS20195 Protein ID WP_000911336.1
Coordinates 4117191..4117589 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag DXN30_RS20200 Protein ID WP_000557549.1
Coordinates 4117589..4117816 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN30_RS20180 (4113867) 4113867..4114451 - 585 WP_001244638.1 fimbrial protein -
DXN30_RS20185 (4115170) 4115170..4115802 - 633 WP_000835265.1 YfdX family protein -
DXN30_RS20190 (4115849) 4115849..4116385 - 537 WP_001038506.1 STM3031 family outer membrane protein -
DXN30_RS20195 (4117191) 4117191..4117589 - 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
DXN30_RS20200 (4117589) 4117589..4117816 - 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
DXN30_RS20205 (4117993) 4117993..4118244 + 252 WP_001540858.1 hypothetical protein -
DXN30_RS20210 (4118519) 4118519..4119325 + 807 WP_010989071.1 DUF1460 domain-containing protein -
DXN30_RS20220 (4119610) 4119610..4120368 - 759 WP_000244329.1 amidase activator ActS -
DXN30_RS20225 (4120633) 4120633..4121178 + 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
DXN30_RS20230 (4121254) 4121254..4122771 - 1518 WP_000003339.1 lysine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 4108745..4119325 10580


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T146556 WP_000911336.1 NZ_CP047542:c4117589-4117191 [Salmonella enterica subsp. enterica serovar Typhimurium]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T146556 NZ_CP062761:c3346644-3346270 [Escherichia coli O157:H7]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT146556 WP_000557549.1 NZ_CP047542:c4117816-4117589 [Salmonella enterica subsp. enterica serovar Typhimurium]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT146556 NZ_CP062761:c3347065-3346691 [Escherichia coli O157:H7]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References