249292

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 879586..880211 Replicon chromosome
Accession NZ_CP099705
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain 013+

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NG892_RS04315 Protein ID WP_080247813.1
Coordinates 879813..880211 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag NG892_RS04310 Protein ID WP_000557549.1
Coordinates 879586..879813 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NG892_RS04280 (874631) 874631..876148 + 1518 WP_000003339.1 lysine--tRNA ligase -
NG892_RS04285 (876224) 876224..876769 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
NG892_RS04290 (877034) 877034..877792 + 759 WP_000244329.1 amidase activator ActS -
NG892_RS04300 (878077) 878077..878883 - 807 WP_010989071.1 DUF1460 domain-containing protein -
NG892_RS04305 (879158) 879158..879409 - 252 WP_001540858.1 hypothetical protein -
NG892_RS04310 (879586) 879586..879813 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
NG892_RS04315 (879813) 879813..880211 + 399 WP_080247813.1 tRNA(fMet)-specific endonuclease VapC Toxin
NG892_RS04320 (881017) 881017..881553 + 537 WP_001038506.1 STM3031 family outer membrane protein -
NG892_RS04325 (881600) 881600..882232 + 633 WP_000835265.1 YfdX family protein -
NG892_RS04330 (882951) 882951..883535 + 585 WP_001244638.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 878077..889402 11325


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14926.24 Da        Isoelectric Point: 7.2155

>T249292 WP_080247813.1 NZ_CP099705:879813-880211 [Salmonella enterica subsp. enterica serovar Typhimurium]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRTEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT249292 WP_000557549.1 NZ_CP099705:879586-879813 [Salmonella enterica subsp. enterica serovar Typhimurium]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References