282768

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 882697..883322 Replicon chromosome
Accession NZ_CP126325
Organism Salmonella enterica subsp. enterica strain HL21

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QN088_RS04260 Protein ID WP_000911337.1
Coordinates 882924..883322 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag QN088_RS04255 Protein ID WP_000557549.1
Coordinates 882697..882924 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN088_RS04240 (879262) 879262..880905 + 1644 WP_284546205.1 group II intron reverse transcriptase/maturase -
QN088_RS04245 (881156) 881156..881962 - 807 WP_010989071.1 DUF1460 domain-containing protein -
QN088_RS04250 (882237) 882237..882488 - 252 WP_001673708.1 hypothetical protein -
QN088_RS04255 (882697) 882697..882924 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
QN088_RS04260 (882924) 882924..883322 + 399 WP_000911337.1 tRNA(fMet)-specific endonuclease VapC Toxin
QN088_RS04265 (884129) 884129..884665 + 537 WP_001038506.1 STM3031 family outer membrane protein -
QN088_RS04270 (884712) 884712..885344 + 633 WP_000835265.1 YfdX family protein -
QN088_RS04275 (886063) 886063..886647 + 585 WP_001244638.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 879262..892507 13245


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15037.43 Da        Isoelectric Point: 7.7785

>T282768 WP_000911337.1 NZ_CP126325:882924-883322 [Salmonella enterica subsp. enterica]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT282768 WP_000557549.1 NZ_CP126325:882697-882924 [Salmonella enterica subsp. enterica]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References