231059

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3859780..3860405 Replicon chromosome
Accession NZ_CP090533
Organism Salmonella enterica strain 2017005-SE

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag L0F61_RS19070 Protein ID WP_000911336.1
Coordinates 3859780..3860178 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag L0F61_RS19075 Protein ID WP_000557549.1
Coordinates 3860178..3860405 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0F61_RS19055 (3856456) 3856456..3857040 - 585 WP_001244638.1 fimbrial protein -
L0F61_RS19060 (3857759) 3857759..3858391 - 633 WP_000835265.1 YfdX family protein -
L0F61_RS19065 (3858438) 3858438..3858974 - 537 WP_001038506.1 STM3031 family outer membrane protein -
L0F61_RS19070 (3859780) 3859780..3860178 - 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
L0F61_RS19075 (3860178) 3860178..3860405 - 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
L0F61_RS19080 (3860582) 3860582..3860833 + 252 WP_001540858.1 hypothetical protein -
L0F61_RS19085 (3861108) 3861108..3861914 + 807 WP_010989071.1 DUF1460 domain-containing protein -
L0F61_RS19095 (3862199) 3862199..3862957 - 759 WP_000244329.1 amidase activator ActS -
L0F61_RS19100 (3863222) 3863222..3863767 + 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
L0F61_RS19105 (3863843) 3863843..3865360 - 1518 WP_000003339.1 lysine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3851334..3861914 10580


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T231059 WP_000911336.1 NZ_CP090533:c3860178-3859780 [Salmonella enterica]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T231059 NZ_CP125903:c1622379-1622128 [Staphylococcus aureus]
ATGAATAATCGCGAACAAATTGAACAATCCGTTATCAGTGCTAGTGCGTATAACGGTAATGATACAGAGGGATTACTAAA
AGAGATTGAGGACGTATATAAGAAAGCGCGAGCGTTTGATGAAATACTTGAAGGTTTACCTAATGCTATGCAAGATGCAC
TCAAAGAAGATATTGGTCTTGATGAAGCAGTAGGGATTATGACGGGGCAAGTGGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT231059 WP_000557549.1 NZ_CP090533:c3860405-3860178 [Salmonella enterica]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT231059 NZ_CP125903:c1622138-1621956 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTACAAGTTATCTGACGGCTCTATTATCAGTCTCATAGACTTTGTTATTAAACCAATTCATTTAATCA
AGGAGGCACAGGAAAATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References