Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 881190..881815 Replicon chromosome
Accession NZ_CP101376
Organism Salmonella enterica strain SC2016091

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag NMU34_RS04295 Protein ID WP_000911336.1
Coordinates 881417..881815 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag NMU34_RS04290 Protein ID WP_000557549.1
Coordinates 881190..881417 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU34_RS04260 (876235) 876235..877752 + 1518 WP_000003339.1 lysine--tRNA ligase -
NMU34_RS04265 (877828) 877828..878373 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
NMU34_RS04270 (878638) 878638..879396 + 759 WP_000244329.1 amidase activator ActS -
NMU34_RS04280 (879681) 879681..880487 - 807 WP_010989071.1 DUF1460 domain-containing protein -
NMU34_RS04285 (880762) 880762..881013 - 252 WP_001540858.1 hypothetical protein -
NMU34_RS04290 (881190) 881190..881417 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
NMU34_RS04295 (881417) 881417..881815 + 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
NMU34_RS04300 (882621) 882621..883157 + 537 WP_001038506.1 STM3031 family outer membrane protein -
NMU34_RS04305 (883204) 883204..883836 + 633 WP_000835265.1 YfdX family protein -
NMU34_RS04310 (884555) 884555..885139 + 585 WP_001244638.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 879681..891006 11325


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T252011 WP_000911336.1 NZ_CP101376:881417-881815 [Salmonella enterica]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT252011 WP_000557549.1 NZ_CP101376:881190-881417 [Salmonella enterica]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References